The role and mechanism of action of microRNA-122 in cancer: Focusing on the liver

•miR-122 has a significant impact on the development and progression of some types of cancer.•miR-122 is a critical regulator of apoptosis in HCC and glioma through targeting Bcl-2 family proteins and the Wnt/β-catenin-TCT signaling pathway.•The regulatory link between SIRT6 and miR-122 in HCC impli...

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Published in:International immunopharmacology 2023-10, Vol.123, p.110713-110713, Article 110713
Main Authors: Al-Gazally, Moaed E., Khan, Ramsha, Imran, Muhammad, Ramírez-Coronel, Andrés Alexis, Alshahrani, Shadia Hamoud, Altalbawy, Farag M.A., Turki Jalil, Abduladheem, Romero-Parra, Rosario Mireya, Zabibah, Rahman S., Shahid Iqbal, Muhammad, Karampoor, Sajad, Mirzaei, Rasoul
Format: Article
Language:English
Subjects:
Apoptosis
Biomarker
Hepatocellualr carcinoma
Lipid metabolism
Metabolic reprograming
Metastasis
miR-122
Proliferation
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Summary:•miR-122 has a significant impact on the development and progression of some types of cancer.•miR-122 is a critical regulator of apoptosis in HCC and glioma through targeting Bcl-2 family proteins and the Wnt/β-catenin-TCT signaling pathway.•The regulatory link between SIRT6 and miR-122 in HCC implies that modulation of miR-122 could serve as a promising therapeutic approach for SIRT6-mediated cancer.•miR-122 regulates cancer proliferation, metastasis, and invasion and interacts with HNF-6 and CREB1, making it a promising cancer treatment target. microRNA-122 (miR-122) is a highly conserved microRNA that is predominantly expressed in the liver and plays a critical role in the regulation of liver metabolism. Recent studies have shown that miR-122 is involved in the pathogenesis of various types of cancer, particularly liver cancer. In this sense, The current findings highlighted the potential role of miR-122 in regulating many vital processes in cancer pathophysiology, including apoptosis, signaling pathway, cell metabolism, immune system response, migration, and invasion. These results imply that miR-122, which has been extensively studied for its biological functions and potential therapeutic applications, acts as a tumor suppressor or oncogene in cancer development. We first provide an overview and summary of the physiological function and mode of action of miR-122 in liver cancer. We will examine the various signaling pathways and molecular mechanisms through which miR-122 exerts its effects on cancer cells, including the regulation of oncogenic and tumor suppressor genes, the modulation of cell proliferation and apoptosis, and the regulation of metastasis. Most importantly, we will also discuss the potential diagnostic and therapeutic applications of miR-122 in cancer, including the development of miRNA-based biomarkers for cancer diagnosis and prognosis, and the potential use of miR-122 as a therapeutic target for cancer treatment.
ISSN:1567-5769
1878-1705
DOI:10.1016/j.intimp.2023.110713