Changing presentation of acromegaly in half a century: a single-center experience

Objective Investigate the changes in the characteristics of presentation, in patients with acromegaly over a period of approximately half a century. Methods The medical records of patients diagnosed with acromegaly between 1980 and 2023 were retrospectively reviewed. The collected data were examined...

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Bibliographic Details
Published in:Pituitary 2023-10, Vol.26 (5), p.573-582
Main Authors: Demir, Ahmet Numan, Sulu, Cem, Kara, Zehra, Sahin, Serdar, Ozaydin, Dilan, Sonmez, Ozge, Keskin, Fatma Ela, Tanriover, Necmettin, Gazioglu, Nurperi, Kadioglu, Pinar
Format: Article
Language:English
Subjects:
Acromegaly
Age
Cancer therapies
Cardiovascular disease
Colon
Colon cancer
Comorbidity
Diabetes
Diabetes mellitus
Diagnosis
Endocrinology
Growth hormones
Human Physiology
Hypertension
Insulin-like growth factor I
Insulin-like growth factors
Medical records
Medicine
Medicine & Public Health
Metabolism
Mortality
Neurosurgery
Patients
Pituitary
Polyps
Remission
Remission (Medicine)
Thyroid cancer
Tumors
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Summary:Objective Investigate the changes in the characteristics of presentation, in patients with acromegaly over a period of approximately half a century. Methods The medical records of patients diagnosed with acromegaly between 1980 and 2023 were retrospectively reviewed. The collected data were examined to assess any changes observed over the years and a comparison was made between the characteristics of patients diagnosed in the last decade and those diagnosed in previous years. Results A total of 570 patients were included in the study, 210 (37%) patients were diagnosed in the last decade. Patients diagnosed before 2014 had longer symptom duration before diagnosis, advanced age, larger pituitary adenomas, higher incidence of cavernous sinus invasion, and higher GH and IGF-1 levels than those diagnosed last decade (p 
ISSN:1386-341X
1573-7403
DOI:10.1007/s11102-023-01344-1