Synthesis of ( E )-2-(1-(methoxyimino)ethyl)-2-phenylbenzofuran-3(2 H )-ones from ( E )-1-(benzofuran-2-yl)ethan-1-one O -methyl oximes and iodobenzenes via a palladium-catalyzed dearomative arylation/oxidation reaction

A new method has been successfully developed that offers a facile and reliable approach for synthesizing ( )-2-(1-(methoxyimino)ethyl)-2-phenylbenzofuran-3(2 )-one, providing 28 compounds. This optimized process enables efficient preparation of a wide range of compounds using readily available ( )-1...

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Bibliographic Details
Published in:Organic & biomolecular chemistry 2023-08, Vol.21 (31), p.6307-6311
Main Authors: Zhu, Wen-Jing, Yu, Xiao, Liu, Hong-Yan, Liu, Yi, Zhao, Jin-Bo, Zhang, Peng-Fei, Xia, Cheng-Cai, Li, Fu-Rong
Format: Article
Language:English
Subjects:
Benzofuran
Ketones
Oxidation
Oximes
Palladium
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Summary:A new method has been successfully developed that offers a facile and reliable approach for synthesizing ( )-2-(1-(methoxyimino)ethyl)-2-phenylbenzofuran-3(2 )-one, providing 28 compounds. This optimized process enables efficient preparation of a wide range of compounds using readily available ( )-1-(benzofuran-2-yl)ethan-1-one -methyl oxime and iodobenzene, and provides alternative ideas for the structural modification of benzofuran ketones.
ISSN:1477-0520
1477-0539
DOI:10.1039/d3ob00772c