Length of Leukocyte Telomeres in Newborns of HIV-Infected Mothers

We studied the relative length of telomeres in newborns with unrealized perinatal transmission of HIV (zero viral load according to PCR results). A cross-sectional survey of 62 newborns of HIV-infected mothers (Apgar score 8); the control group consisted of 80 healthy newborns (Apgar score 8). DNA e...

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Bibliographic Details
Published in:Bulletin of experimental biology and medicine 2023-06, Vol.175 (2), p.260-264
Main Authors: Kurashova, N. A., Vanyarkina, A. S., Petrova, A. G., Rychkova, L. V., Kolesnikov, S. I., Darenskaya, M. A., Moskaleva, E. V., Kolesnikova, L. I.
Format: Article
Language:English
Subjects:
Analysis
Antiretroviral therapy
Antiviral agents
Apgar score
Biomedical and Life Sciences
Biomedicine
Cell Biology
Children & youth
Disease transmission
Ecology
Ethylenediaminetetraacetic acid
Families & family life
Genetic testing
Genomes
Gestational age
Highly active antiretroviral therapy
HIV
HIV (Viruses)
HIV infection
HIV patients
Human immunodeficiency virus
Infants (Newborn)
Infections
Internal Medicine
Laboratory Medicine
Leukocytes
Medical research
Medicine, Experimental
Mothers
Neonates
Pathology
Pregnancy
Pregnant women
Surveys
Telomerase
Telomeres
Womens health
Yeast
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Summary:We studied the relative length of telomeres in newborns with unrealized perinatal transmission of HIV (zero viral load according to PCR results). A cross-sectional survey of 62 newborns of HIV-infected mothers (Apgar score 8); the control group consisted of 80 healthy newborns (Apgar score 8). DNA extracted from whole venous blood samples was analyzed. In newborns of HIV-infected mothers, the relative length of telomeres was significantly lower (0.69 (0.66; 0.72)) than in newborns of the control group (1.1 (0.97; 1.22)) ( p
ISSN:0007-4888
1573-8221
DOI:10.1007/s10517-023-05846-7