Clinical characteristics and outcomes of Clostridioides difficile infection in the intensive care unit: a KASID multi-centre study

Despite the growing clinical and economic burden of Clostridioides difficile infection (CDI), data on CDI in the intensive care unit (ICU) in the Asia-Pacific region are lacking. This retrospective study analysed 191 patients who were treated with CDI in the ICUs of three hospitals in South Korea fr...

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Bibliographic Details
Published in:The Journal of hospital infection 2023-09, Vol.139, p.106-112
Main Authors: Baek, J.E., Choi, I.H., Cho, Y.W., Kim, J., Lee, Y.J., Kim, M.C., Kim, K.O., Cho, Y-S.
Format: Article
Language:English
Subjects:
Clostridioides difficile
Diarrhoea
Intensive care unit
Mortality
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Summary:Despite the growing clinical and economic burden of Clostridioides difficile infection (CDI), data on CDI in the intensive care unit (ICU) in the Asia-Pacific region are lacking. This retrospective study analysed 191 patients who were treated with CDI in the ICUs of three hospitals in South Korea from January 2017 to May 2021. Backward-stepwise multiple logistic regression was used to identify factors influencing the treatment response and mortality. Fifty-eight patients (30.4%) were considered immunocompromised. The mean Charlson comorbidity index was 5.65 ± 2.39 (10-year survival rate: 21%), the APACHE II score was 20.86 ± 7.78 (mortality rate: 40%), the ATLAS score was 5.45 ± 1.59 (cure rate: 75%), and the SOFA score was 7.97 ± 4.03 (mortality rate: 21.5%). Fifty-eight (30.4%) of the CDI cases were severe and 40 (20.9%) were fulminant. Oral vancomycin or oral metronidazole was the most frequently first-line treatments (N = 57; 32.6%). The 10-day response rate was 59.7% and the eight-week overall mortality rate was 41.4%. Fulminant CDI (OR 0.230; 95% CI 0.085–0.623) and each one-unit increment in the SOFA score (OR 0.848; 95% CI 0.759–0.947) were associated with treatment failure. High APACHE II (OR 0.355; 95% CI 0.143–0.880) and SOFA (OR 0.164; 95% CI 0.061–0.441) scores were associated with higher mortality. High-risk patients in the ICU had a higher mortality rate and a lower cure rate of CDI. Further research is required to provide more accurate prediction scoring systems and better clinical outcomes.
ISSN:0195-6701
1532-2939
DOI:10.1016/j.jhin.2023.07.002