Resting energy expenditure measured by indirect calorimetry in mechanically ventilated patients during ICU stay and post-ICU hospitalization: A prospective observational study

The metabolic course during and after critical illness is unclear. We performed repeated indirect calorimetry (IC) measurements during ICU- and post-ICU hospitalization to determine resting energy expenditure (REE). Prospective observational design. In ventilated ICU patients, IC measurements were p...

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Bibliographic Details
Published in:Journal of critical care 2023-12, Vol.78, p.154361-154361, Article 154361
Main Authors: Moonen, Hanneke P.F.X., Hermans, Anoek J.H., Bos, Anneloes E., Snaterse, Ilana, Stikkelman, Eline, van Zanten, Florianne J.L., van Exter, Sabien H., van de Poll, Marcel C.G., van Zanten, Arthur R.H.
Format: Article
Language:English
Subjects:
Body mass index
Coronaviruses
COVID-19
Critical care
Electronic health records
Energy
Energy expenditure
Extubation
Hospitals
Hypermetabolism
Illnesses
Indirect calorimetry
Length of stay
Medical records
Metabolism
Nutrition
Observational studies
Parenteral nutrition
Patients
Physiology
Quality of life
Respiratory quotient
Ventilators
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Summary:The metabolic course during and after critical illness is unclear. We performed repeated indirect calorimetry (IC) measurements during ICU- and post-ICU hospitalization to determine resting energy expenditure (REE). Prospective observational design. In ventilated ICU patients, IC measurements were performed every three days until hospital discharge. Measured REE as predicted by the Harris-Benedict equation (HBE-REE) and 25 kcal/adjusted body weight/day (25-REE) were compared. In 56 patients (38% females, 71[13]years, BMI 29(27;31)kg/m2), 189 ICU IC measurements were performed. Measured REE did not differ from HBE-REE at ICU admission, but was lower than 25-REE. Measured REE was increased compared to baseline on ICU-admission-day four (29(29–30)kcal/kg/day; mean difference 3.1(1.4–4.9)kcal/kg/day, p  110% of predicted REE on ICU admission day four and thereafter. Indirect calorimetry measurements suggest that the mean energy requirements during post-ICU hospitalization are higher than those in the ICU. [Display omitted] •Resting energy expenditure measured within 24 h of ICU admission was not higher than predicted.•Patients were hypermetabolic on ICU admission day four and thereafter.•Energy requirements increased when patients were discharged from the ICU to the ward.
ISSN:0883-9441
1557-8615
DOI:10.1016/j.jcrc.2023.154361