Interferon-gamma plasma levels and presence of mouse mammary tumor virus-like env gene: Implications on the pathogenesis of breast cancer

•A decrease in IFN-γ levels was observed in BC patients compared to control group.•IFN-γ plasma levels is not associated with the presence of the MMTV-like DNA.•IFN-γ were higher in patients with clinicopathological parameters of worse prognosis.•We observed a potential controversial role of the IFN...

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Published in:Cytokine (Philadelphia, Pa.) Pa.), 2023-09, Vol.169, p.156299-156299, Article 156299
Main Authors: de Sousa Pereira, Nathália, Motoori-Fernandes, Caroline, Banin-Hirata, Bruna Karina, Vitiello, Glauco Akelinghton Freire, de Oliveira, Carlos Eduardo Coral, Amarante, Marla Karine, Watanabe, Maria Angelica Ehara
Format: Article
Language:English
Subjects:
Antiviral
Breast carcinoma
IFN-gamma
Tumor microenvironment
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Summary:•A decrease in IFN-γ levels was observed in BC patients compared to control group.•IFN-γ plasma levels is not associated with the presence of the MMTV-like DNA.•IFN-γ were higher in patients with clinicopathological parameters of worse prognosis.•We observed a potential controversial role of the IFN-γ in BC microenvironment. Mouse mammary tumor virus (MMTV) is a retrovirus that has been associated with the development of breast cancer (BC) in mice. The identification of a 95% homologous gene sequence to MMTV in human BC samples has increased interest in this hypothesis. This virus in humans received the name of mouse mammary tumor virus-like (MMTV-like). Several cytokines may be involved in the interactions between MMTV and the immune system, such as interferon-gamma (IFN-γ), which can enhance Th1-mediated antitumor immune response but it can also play a protumorigenic role by transmitting antiapoptotic and proliferative signals. Little is known about the antiviral immune response in a microenvironment with the presence of MMTV-like in BC patients. Therefore, the purpose of the present study was to quantify the plasma levels of IFN-γ in the peripheral blood of 123 neoplasia-free donors and 98 BC patients of different molecular subtypes, by enzyme-linked immunosorbent assay (ELISA), and evaluate the association of these plasma levels with the detection of the MMTV-like env gene in tumor tissue. Correlation analyzes involving IFN-γ plasma levels and clinical-pathological parameters were performed by Kendall Tau-c test. In our study, a decrease in IFN-γ levels was observed in the group of BC patients (30.85 ± 57.49 pg/ml) compared to the control group (115.00 ± 176.80 pg/ml) (p 
ISSN:1043-4666
1096-0023
DOI:10.1016/j.cyto.2023.156299