Cascade Synthesis of Fluorinated Spiroheterocyclic Scaffolding for Peptidic Macrobicycles

Octafluorocyclopentene (OFCP) engages linear, unprotected peptides in polysubstitution cascades that generate complex fluorinated polycycles. The reactions occur in a single flask at 0–25 °C and require no catalysts or heavy metals. OFCP can directly polycyclize linear sequences using native functio...

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Bibliographic Details
Published in:Journal of the American Chemical Society 2023-07, Vol.145 (29), p.15888-15895
Main Authors: Mendoza, Angel, Bernardino, Salvador J., Dweck, Morris J., Valencia, Isabel, Evans, Declan, Tian, Haowen, Lee, William, Li, Yu, Houk, Kendall N., Harran, Patrick G.
Format: Article
Language:English
Subjects:
Membranes, Artificial
Peptides - chemistry
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Summary:Octafluorocyclopentene (OFCP) engages linear, unprotected peptides in polysubstitution cascades that generate complex fluorinated polycycles. The reactions occur in a single flask at 0–25 °C and require no catalysts or heavy metals. OFCP can directly polycyclize linear sequences using native functionality, or fluorospiroheterocyclic intermediates can be intercepted with exogenous nucleophiles. The latter tactic generates molecular hybrids composed of peptides, sugars, lipids, and heterocyclic components. The platform can create stereoisomers of both single- and double-looped macrocycles. Calculations indicate that the latter can mimic diverse protein surface loops. Subsets of the molecules have low energy conformers that shield the polar surface area through intramolecular hydrogen bonding. A significant fraction of OFCP-derived macrocycles tested show moderate to high passive permeability in parallel artificial membrane permeability assays.
ISSN:0002-7863
1520-5126
DOI:10.1021/jacs.3c03071