Fabrication and characterization of chlorhexidine gluconate loaded poly(vinyl alcohol)/45S5 nano-bioactive glass nanofibrous membrane for guided tissue regeneration applications

Polymeric barrier membranes are used in periodontal applications to prevent fibroblastic cell migration into the cavities of bone tissue and to properly guide the proliferation of tissues. In this study, the fabrication, characterization, bioactivity, and in vitro biological properties of polyvinyl...

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Bibliographic Details
Published in:Biopolymers 2023-10, Vol.114 (10), p.e23562-e23562
Main Authors: Keçeciler-Emir, Ceren, Başaran-Elalmiş, Yeliz, Şahin, Yeşim Müge, Buluş, Erdi, Yücel, Sevil
Format: Article
Language:English
Subjects:
Biocompatibility
Bioglass
Biological activity
Biological properties
Cell migration
Chlorhexidine
Dental caries
Membranes
Polyvinyl alcohol
Pore size
Porosity
Regeneration
Regeneration (physiology)
Tissue engineering
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Summary:Polymeric barrier membranes are used in periodontal applications to prevent fibroblastic cell migration into the cavities of bone tissue and to properly guide the proliferation of tissues. In this study, the fabrication, characterization, bioactivity, and in vitro biological properties of polyvinyl alcohol-based nanofibrous membranes containing nano-sized 45S5 bioactive glass (BG) loaded with chlorhexidine (CH) gluconate with biocompatible, bioactive, and antibacterial properties for using as dental barrier membranes were investigated. Nanofibrous membranes with an average fiber diameter, pore size, and porosity of 210 nm, 24.73 μm, and 12.42%, respectively, were loaded with 1% and 2% CH, and the release profile was investigated. The presence of BG in the membranes promoted fibroblastic proliferation and the presence of CH provided antibacterial properties. Nanofibrous membranes exhibit a high ability to restrict bacterial growth while fulfilling the necessary conditions for use as a dental barrier thanks to their low swelling rates, significant surface bioactivities, and appropriate degradation levels.
ISSN:0006-3525
1097-0282
DOI:10.1002/bip.23562