PreCancer Atlas: Present and Future

Precancer atlases have the potential to revolutionize how we think about the topographic and morphologic structures of precancerous lesions in relation to cellular, molecular, genetic, and pathophysiologic states. This mini review uses the Human Tumor Atlas Network (HTAN), established by the Nationa...

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Bibliographic Details
Published in:Cancer prevention research (Philadelphia, Pa.) Pa.), 2023-07, Vol.16 (7), p.379-384
Main Authors: Srivastava, Sudhir, Wagner, Paul D, Hughes, Shannon K, Ghosh, Sharmistha
Format: Article
Language:English
Subjects:
Humans
National Cancer Institute (U.S.)
Precancerous Conditions - pathology
United States
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Summary:Precancer atlases have the potential to revolutionize how we think about the topographic and morphologic structures of precancerous lesions in relation to cellular, molecular, genetic, and pathophysiologic states. This mini review uses the Human Tumor Atlas Network (HTAN), established by the National Cancer Institute (NCI), to illustrate the construction of cellular and molecular three-dimensional atlases of human cancers as they evolve from precancerous lesions to advanced disease. We describe the collaborative nature of the network and the research to determine how and when premalignant lesions progress to invasive cancer, regress or obtain a state of equilibrium. We have attempted to highlight progress made by HTAN in building precancer atlases and discuss possible future directions. It is hoped that the lessons from our experience with HTAN will help other investigators engaged in the construction of precancer atlases to crystallize their thoughts on logistics, rationale, and implementation.
ISSN:1940-6207
1940-6215
DOI:10.1158/1940-6207.CAPR-22-0435