Phytochemical characterization, antioxidant and antibacterial activities of crude extracts of Anisomeles malabarica and Coldenia procumbens

The aim of this study was to determine the phytochemical profile, antibacterial and antioxidant activities of crude aqueous leaf extracts of Anisomeles malabarica and Coldenia procumbens. The predominant components present in these crude extracts of test plants identified using gas chromatography-ma...

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Bibliographic Details
Published in:Journal of Toxicology and Environmental Health, Part A Part A, 2023-09, Vol.86 (17), p.614-631
Main Authors: Revathi, Ramalingam, Akash, R., Mahadevi, Ramasamy, Sengottuvelu, Singaravel, Mohanraj, Palanisamy, Vijayakumar, Natesan, Krishnamoorthy, Rajapandiyan, Ahmed, Mohammad Z., Kazmi, Shadab, Kavitha, Ramamoorthy
Format: Article
Language:English
Subjects:
Anisomeles malabarica
Anti-Bacterial Agents - chemistry
Anti-Bacterial Agents - pharmacology
Antibacterial activity
antioxidant
Antioxidants
Antioxidants - chemistry
Antioxidants - pharmacology
Bacteria
Coldenia
coldenia procumbens
E coli
Flavonoids
Fluorescence
Fluorescence recovery after photobleaching
Free radicals
Gas chromatography
GC-MS analysis
Hydrogen Peroxide
Klebsiella
Mass spectrometry
Mass spectroscopy
Phenols
Photobleaching
Phytochemicals
Phytochemicals - chemistry
Phytochemicals - pharmacology
Plant extracts
Plant Extracts - chemistry
Plant Extracts - pharmacology
Terpenes
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Summary:The aim of this study was to determine the phytochemical profile, antibacterial and antioxidant activities of crude aqueous leaf extracts of Anisomeles malabarica and Coldenia procumbens. The predominant components present in these crude extracts of test plants identified using gas chromatography-mass spectrometry (GC-MS) analysis in both plant extracts were phytochemicals including flavonoids, tannins, terpenoids, and phenols. The antibacterial activity of crude extracts of these plants against bacterial pathogens including Escherichia coli, Bacillus subtilis, Shigella sp., Salmonella paratyphi A and B, Proteus mirabilis, Proteus vulgaris, Pseudomonas sp. Klebsiella pneumoniae, and Staphylococcus aureus were examined. Data demonstrated that the extracts of A. malabarica and C. procumbens exhibited significant antibacterial activity against B.subtilis and P.vulgaris at the concentration of 50 mg/ml. A. malabarica aqueous extract displayed significant antioxidant activity on 2,2-diphenyl-1-picrylhydrazl (DPPH), fluorescence recovery after photobleaching (FRAP) and hydrogen peroxide (H 2 O 2 ) free radicals at the concentration of 90 mg/ml. The antioxidant activity was significantly higher with A. malabarica than extract of C. procumbens. Evidence indicates that both plant extracts may possess significant pharmaceutical potential as antibacterial and antioxidant agents.
ISSN:1528-7394
1087-2620
2381-3504
DOI:10.1080/15287394.2023.2231484