Low‐risk HPLLs/ABC score patients with splenic marginal zone lymphoma can be safely managed without treatment: Results from a prospective Spanish study

Summary The aims of our study were to analyse compliance with the 2014 GELTAMO SMZL Guidelines, in patients with splenic marginal zone lymphoma (SMZL), and to evaluate the outcome according to the HPLLs/ABC‐adapted therapeutic strategy. Observational prospective multicenter study of 181 SMZL patient...

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Published in:British journal of haematology 2023-08, Vol.202 (4), p.776-784
Main Authors: Muntañola, Ana, Villalobos, María Teresa, González‐Villambrosia, Sonia, Rodríguez‐Salazar, María José, Jiménez‐Ubieto, Ana, Bastidas‐Mora, Gabriela, Córdoba, Raúl, Infante, María, Vidal, María Jesús, Díaz, Francisco Javier, Baile, Mónica, Bastos‐Oreiro, Mariana, Panizo, Carlos, Sancho, Juan Manuel, Navarro, Belén, García, Tomás, Escoda, Lourdes, Abrisqueta, Pau, Terol, María José, Campo, Raquel, Mozas, Pablo, López‐Guillermo, Armando, Salar, Antonio, Montalbán, Carlos
Format: Article
Language:English
Subjects:
Chemotherapy
Hematology
HPLLs/ABC score
Lymphoma
Rituximab
SMZL Spanish Guidelines
Spleen
Splenectomy
splenic marginal zone lymphoma (SMZL)
Survival
therapeutic management
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Summary:Summary The aims of our study were to analyse compliance with the 2014 GELTAMO SMZL Guidelines, in patients with splenic marginal zone lymphoma (SMZL), and to evaluate the outcome according to the HPLLs/ABC‐adapted therapeutic strategy. Observational prospective multicenter study of 181 SMZL patients diagnosed between 2014 and 2020. Lymphoma‐specific survival (LSS), composite event‐free survival (CEFS) and response rates were assessed. 57% of the 168 patients included in the analysis followed the Guidelines. The overall response rate was higher in the rituximab chemotherapy and in the rituximab arms compared with the splenectomy arm (p 
ISSN:0007-1048
1365-2141
DOI:10.1111/bjh.18912