Peripheral T-cell lymphoma with a T follicular-helper phenotype: A different entity? Results of the Spanish Real-T study

Nodal peripheral T-cell lymphoma (PTCL) with a T follicular helper phenotype (PTCL-TFH) is a new type of PTCL. We aimed to define its clinical characteristics and prognosis compared to PTCL not otherwise specified (PTCL-NOS) and angioimmunoblastic T-cell lymphoma (AITL). This retrospective observati...

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Published in:British journal of haematology 2023-10, Vol.203 (2), p.182-193
Main Authors: Martín García-Sancho, Alejandro, Rodríguez-Pinilla, Socorro M, Domingo-Domenech, Eva, Climent, Fina, Sánchez-Garcia, Joaquín, López Jiménez, Javier, García-Cosío Piqueras, Mónica, Castellvi, Josep, González, Ana Julia, González de Villambrosia, Sonia, Gómez Codina, José, Navarro, Belén, Rodríguez, Guillermo, Borrero, Juan José, Fraga, Máximo, Naves, Andrea, Baeza, Lourdes, Córdoba, Raúl
Format: Article
Language:English
Subjects:
Diagnosis
Hematology
Lymphoma
Medical prognosis
Phenotypes
Prognosis
T-cell lymphoma
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Summary:Nodal peripheral T-cell lymphoma (PTCL) with a T follicular helper phenotype (PTCL-TFH) is a new type of PTCL. We aimed to define its clinical characteristics and prognosis compared to PTCL not otherwise specified (PTCL-NOS) and angioimmunoblastic T-cell lymphoma (AITL). This retrospective observational study included 175 patients diagnosed with PTCL between 2008 and 2013 in 13 Spanish sites. Patient diagnosis was centrally reviewed, and patients were reclassified according to the World Health Organization (WHO) 2016 criteria: 21 patients as PTCL-NOS, 55 as AITL and 23 as PTCL-TFH. Median follow-up was 56.07 months (95% CI 38.7-73.4). Progression-free survival (PFS) and overall survival (OS) were significantly higher in patients with PTCL-TFH than in those with PTCL-NOS and AITL (PFS, 24.6 months vs. 4.6 and 7.8 months, respectively, p = 0.002; OS, 52.6 months vs. 10.0 and 19.3 months, respectively, p 
ISSN:0007-1048
1365-2141
DOI:10.1111/bjh.18941