Hepatitis C virus transmission between eight high-income countries among men who have sex with men: a whole-genome analysis

Microelimination of the hepatitis C virus (HCV) among men who have sex with men (MSM) could be complicated by continuous external introductions and the emergence of phylogenetic clusters harbouring clinically significant resistance-associated substitutions (RAS). To investigate international cluster...

Full description

Saved in:

Bibliographic Details
Published in:	The Lancet. Microbe 2023-08, Vol.4 (8), p.e622-e631
Main Authors:	Koopsen, Jelle, Matthews, Gail, Rockstroh, Juergen, Applegate, Tanya L, Bhagani, Sanjay, Rauch, Andri, Grebely, Jason, Sacks-Davis, Rachel, Ingiliz, Patrick, Boesecke, Christoph, Rebers, Sjoerd, Feld, Jordan, Bruneau, Julie, Martinello, Marianne, Hellard, Margaret, Dore, Gregory J, Schinkel, Janke, van der Valk, Marc, Adams, Tanya, Amjad, Sophia, Appelhans, Christina, Applegate, Tanya, Becker, Brigitta, Bouchard, Rachel, Braun, Dominique, Bruelisauer, Christine, Calcagnile, Selma, Carroll, Anne, Cerocchi, Orlando, Chronister, Karen, Cordes, Christiane, Dore, Greg, Evans, Fiona, Fedele, Serge, Ferguson, Catherine, Fraser, Chris, Ganase, Bruce, Gane, Ed, George, Valerie, Gerlach, Christoph, Gilleece, Yvonne, Gilliver, Rosie, Grube, Christina, Gustafson, Jenna, Haas, Annette, Hagenauer, Michelle, Harris, Marianne, Helder, Jeltje, Hirter, Daniela, Hull, Mark, Katz, Stephanie, Kim, Arthur, Kotsoros, Barbara, Lacalamita, Melanie, Lindergard, Gabriella, Lutz, Thomas, Macabodbod, Lester, Manz, Manuela, Marks, Pip, Messina, Paola, Mohrmann, Karina, Monnich, Christine, Moon, Juhi, Moriggia, Alberto, Morris, Genevieve, Morrish, Thomas, Nelson, Mark, Oliver, Victoria, Patterson, Joanne, Peters, Martine, Petoumenos, Kathy, Porretta, Hadassa, Raymode, Parizade, Read, Phillip, Reece, Stacey, Rockstroh, Jürgen, Saidi, Angelika, Sasadeusz, Joe, Scherler, Pia, Schröder, Reinhold, Selfridge, Marion, Sevehon, Alison, Shaw, David, Sulkowski, Mark, Tamaddoni, Mahshid, Thunder, Orla, Thurnheer, Maria Christine, Tu, Elise, Ustianowski, Andrew, Witele, Eric
Format:	Article
Language:	eng
Subjects:	Bayes Theorem Developed Countries Hepacivirus - genetics Hepatitis C - epidemiology HIV Infections - epidemiology Homosexuality, Male Humans Male Phylogeny Sexual and Gender Minorities United States
Online Access:	Get full text
Tags:	Add Tag No Tags, Be the first to tag this record!

Description
Summary:	Microelimination of the hepatitis C virus (HCV) among men who have sex with men (MSM) could be complicated by continuous external introductions and the emergence of phylogenetic clusters harbouring clinically significant resistance-associated substitutions (RAS). To investigate international clustering and the prevalence and transmission of RAS, we aimed to analyse whole-genome HCV sequences from MSM with a recently acquired infection who participated in a large, international HCV treatment trial. For this whole-genome analysis, we obtained HCV sequences from 128 MSM who had acquired HCV within the past 12 months and were participating in the REACT trial. The participants from whom sequences were obtained were recruited at 24 sites in eight countries. We inferred maximum-likelihood phylogenies and identified transmission clusters for HCV genotypes separately. We constructed time-scaled phylogenies to estimate cluster introduction dates and used a Bayesian Skygrid approach to estimate the effective population size over the past 50 years. We calculated the prevalence of RAS and the extent of RAS transmission in the study population. The majority of recent HCV infections were part of international networks that arose in the late 1990s and early 2000s. Sequences obtained in the same country clustered frequently, and in 36% of subclusters since 2015 we found evidence of international transmission. European MSM were more likely than non-European MSM to be in a cluster (odds ratio 11·9 [95% CI 3·6–43·4], p
ISSN:	2666-5247 2666-5247