Participation of cAMP-Mediated Signaling Transduction in the Regulation of the Secretory Function of Neuroglia during Ethanol-Induced Neurodegeneration

We studied the involvement of cAMP and PKA in the regulation of the secretion of neurotrophic growth factors by macro-and microglial cells in the model of ethanol-induced neurodegeneration in vitro and in vivo . The stimulating role of cAMP in the secretion of neurotrophins by intact astrocytes and...

Full description

Saved in:
Bibliographic Details
Published in:Bulletin of experimental biology and medicine 2023-05, Vol.175 (1), p.12-16
Main Authors: Zyuz’kov, G. N., Zhdanov, V. V., Miroshnichenko, L. A., Polyakova, T. Yu, Simanina, E. V., Danilets, M. G., Agafonov, V. I., Stavrova, L. A.
Format: Article
Language:English
Subjects:
Acetaldehyde
Alcohol
Alcohol, Denatured
Analysis
Astrocytes
Astrocytes - metabolism
Biomedical and Life Sciences
Biomedicine
Cell Biology
Cellular signal transduction
Cyclic adenylic acid
Cyclic AMP
Cyclic AMP - metabolism
Cyclic AMP-Dependent Protein Kinases - genetics
Cyclic AMP-Dependent Protein Kinases - metabolism
Ethanol
Ethanol - toxicity
Glia
Growth factors
Internal Medicine
Laboratory Medicine
Microglial cells
Neurodegeneration
Neurogenesis
Neurotrophic factors
Oligodendrocytes
Pathology
Protein kinase A
Secretion
Signal Transduction
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:We studied the involvement of cAMP and PKA in the regulation of the secretion of neurotrophic growth factors by macro-and microglial cells in the model of ethanol-induced neurodegeneration in vitro and in vivo . The stimulating role of cAMP in the secretion of neurotrophins by intact astrocytes and oligodendrocytes was shown, while PKA does not participate in this process. On the contrary, the inhibitory role of cAMP (implemented via PKA activation) in the production of neurogenesis stimulators by microglial cells under conditions of optimal vital activity was found. Under the influence of ethanol, the role of cAMP and PKA in the production of growth factors by macroglial cells was considerably changed. The involvement of PKA in the cAMP-dependent signaling pathways and inversion of the role of this signaling pathway in the implementation of the neurotrophic secretory function of astrocytes and oligodendrocytes, respectively, directly exposed to ethanol in vitro were noted. Long-term exposure of the nervous tissue to ethanol in vivo led to the loss of the stimulating role of cAMP/PKA signaling on neurotrophin secretion by macroglial cells without affecting its inhibitory role in the regulation of this function in microglial cells.
ISSN:0007-4888
1573-8221
DOI:10.1007/s10517-023-05800-7