Development and validation of nomogram to improve the specificity of multiparametric MRI for clinically significant prostate cancer

To develop and validate a nomogram to improve the specificity of prostate imaging reporting and data system (PI-RADS) on multiparametric magnetic resonance imaging (MRI) for clinically significant prostate cancer on targeted fusion biopsy. A retrospective review of patients who underwent fusion biop...

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Bibliographic Details
Published in:International journal of urology 2023-10, Vol.30 (10), p.876-882
Main Authors: Shiekh, Mohsin, Houenstein, Holly, Ramahi, Yousuf O, Shabir, Usma, Ghadersohi, Sarah, Zhu, Denzel, Zhu, Michael, Jing, Zhe, Attwood, Kristopher, Kauffman, Eric, Aboumohamed, Ahmed, Guru, Khurshid, Hussein, Ahmed A
Format: Article
Language:English
Subjects:
Biopsy
Clinical significance
Lesions
Magnetic resonance imaging
Prostate cancer
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Summary:To develop and validate a nomogram to improve the specificity of prostate imaging reporting and data system (PI-RADS) on multiparametric magnetic resonance imaging (MRI) for clinically significant prostate cancer on targeted fusion biopsy. A retrospective review of patients who underwent fusion biopsy for PI-RADS 3-5 lesions using UroNav and Artemis systems between 2016 and 2022 was performed. Patients were divided into those with CS disease on fusion biopsy (Gleason grade group ≥2) versus those without. Multivariable analysis was used to identify variables associated with CS disease. A 100-point nomogram was constructed, and ROC curve was generated. 1485 lesions (1032 patients) were identified, 510 (34%) were PI-RADS 3, 586 (40%) were PI-RADS 4, and 389 (26%) were PI-RADS 5. Of these, 11% of PI-RADS 3, 39% of PI-RADS 4, and 61% of PI-RADS 5 showed CS disease. CS disease was associated with older age (OR 1.04, 95% CI 1.02-1.06, p 
ISSN:0919-8172
1442-2042
DOI:10.1111/iju.15225