T cell immune profiling of respiratory syncytial virus for the development of a targeted immunotherapy

Summary Respiratory syncytial virus (RSV)‐associated viral infections are a major public health problem affecting the immunologically naïve/compromised populations. Given the RSV‐associated morbidity and the limited treatment options, we sought to characterize the cellular immune response to RSV to...

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Bibliographic Details
Published in:British journal of haematology 2023-08, Vol.202 (4), p.874-878
Main Authors: Papayanni, Penelope Georgia, Koukoulias, Kiriakos, Kuvalekar, Manik, Watanabe, Ayumi, Velazquez, Yovana, Ramos, Carlos A., Leen, Ann M., Vasileiou, Spyridoula
Format: Article
Language:English
Subjects:
adoptive immunotherapy
antigen immunodominance
Antiviral activity
Cell therapy
Hematology
Hematopoietic stem cells
immune compromised patients
Immune response (cell-mediated)
Immunotherapy
Lymphocytes T
Morbidity
off‐the‐shelf
Public health
Respiratory syncytial virus
respiratory syncytial virus (RSV)
Stem cell transplantation
Viruses
virus‐specific T cells
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Summary:Summary Respiratory syncytial virus (RSV)‐associated viral infections are a major public health problem affecting the immunologically naïve/compromised populations. Given the RSV‐associated morbidity and the limited treatment options, we sought to characterize the cellular immune response to RSV to develop a targeted T cell therapy for off‐the‐shelf administration to immunocompromised individuals. Here we report on the immunological profiling, as well as manufacturing, characterization and antiviral properties of these RSV‐targeted T cells. A randomized, phase 1/2 clinical trial evaluating their safety and activity in haematopoietic stem cell transplant recipients as an off‐the‐shelf multi‐respiratory virus‐directed product is currently underway (NCT04933968, https://clinicaltrials.gov).
ISSN:0007-1048
1365-2141
DOI:10.1111/bjh.18933