Trends and challenges in microfluidic methods for protein manipulation—A review

Proteins are important molecules involved in an immensely large number of biological processes. Being capable of manipulating proteins is critical for developing reliable and affordable techniques to analyze and/or detect them. Such techniques would enable the production of therapeutic agents for th...

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Bibliographic Details
Published in:Electrophoresis 2024-01, Vol.45 (1-2), p.69-100
Main Authors: de los Santos‐Ramirez, J. Martin, Boyas‐Chavez, Pablo G., Cerrillos‐Ordoñez, Andres, Mata‐Gomez, Marco, Gallo‐Villanueva, Roberto C., Perez‐Gonzalez, Victor H.
Format: Article
Language:English
Subjects:
Biological activity
Bioreactors
Lab-On-A-Chip Devices
lab‐on‐a‐chip
Microfluidic Analytical Techniques - methods
Microfluidics
Microfluidics - methods
Nanoparticles - chemistry
Pharmacology
point‐of‐care
Proteins
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Summary:Proteins are important molecules involved in an immensely large number of biological processes. Being capable of manipulating proteins is critical for developing reliable and affordable techniques to analyze and/or detect them. Such techniques would enable the production of therapeutic agents for the treatment of diseases or other biotechnological applications (e.g., bioreactors or biocatalysis). Microfluidic technology represents a potential solution to protein manipulation challenges because of the diverse phenomena that can be exploited to achieve micro‐ and nanoparticle manipulation. In this review, we discuss recent contributions made in the field of protein manipulation in microfluidic systems using different physicochemical principles and techniques, some of which are miniaturized versions of already established macro‐scale techniques.
ISSN:0173-0835
1522-2683
DOI:10.1002/elps.202300056