Bioinsecticidal activity of cajeput oil to pyrethroid-susceptible and -resistant mosquitoes

Mosquito-borne diseases are a significant threat to human health. The frequent and repetitive application of insecticides can result in the selection of resistant mosquito populations leading to product failures for reducing community disease transmission. It is important that new interventions are...

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Bibliographic Details
Published in:Pesticide biochemistry and physiology 2023-06, Vol.193, p.105458-105458, Article 105458
Main Authors: Johnson, Ellis J., McComic, Sarah E., Rault, Leslie C., Swale, Daniel R., Anderson, Troy D.
Format: Article
Language:English
Subjects:
Aedes aegypti
Cajeput oil
cAMP, AChE, CNS
Toxicity
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Summary:Mosquito-borne diseases are a significant threat to human health. The frequent and repetitive application of insecticides can result in the selection of resistant mosquito populations leading to product failures for reducing community disease transmission. It is important that new interventions are discovered and developed for reducing mosquito populations and, in turn, protecting human health. Plant essential oils are promising chemical interventions for reducing mosquito populations. The myrtle family, Myrtaceae, has numerous species to be studied as potential bioinsecticides. Here, we combined toxicological, biochemical, and neurophysiological approaches to provide evidence for cajeput oil and terpene constituents to elicit bioinsecticidal activity to pyrethroid-susceptible and -resistant Aedes aegypti. We show cajeput oil terpenes to enhance cAMP production, increase ACh levels, inhibit in vivo and in vitro AChE activity, and disrupt spike discharge frequencies of the mosquito CNS. This study presents the first report on the bioinsecticidal activity of cajeput oil terpenes to pyrethroid-susceptible and -resistant mosquitoes and provides comparative data for the octopaminergic system as a putative molecular target for the bioinsecticides with implications for resistance management. [Display omitted] •Cajeput oil terpenes are acutely toxic to pyrethroid-susceptible and -resistant Aedes aegypti.•Phentolamine and epinastine reduce mortality of mosquitoes exposed to cajeput oil terpenes.•Amitraz and chlordimeform enhance mortality of mosquitoes exposed to cajeput oil terpenes.•Cajeput oil terpenes enhance cAMP, increase ACh, inhibit AChE, and disrupt CNS spike discharge frequencies in mosquitoes.
ISSN:0048-3575
1095-9939
DOI:10.1016/j.pestbp.2023.105458