Anodic Cyclizations and Umpolung Reactions Involving Imines

Recent discoveries that anodic cyclization reactions rely heavily on the success of a second electron oxidation downstream of the cyclization suggest that this second electron oxidation step can be used to channel a reaction down new synthetic pathways. Here we describe one such application that rev...

Full description

Saved in:
Bibliographic Details
Published in:Organic letters 2023-06, Vol.25 (22), p.4135-4139
Main Authors: Medcalf, Zach, Redd, Essence G., Oh, Jaemyeong, Ji, Chang, Moeller, Kevin D.
Format: Article
Language:English
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Recent discoveries that anodic cyclization reactions rely heavily on the success of a second electron oxidation downstream of the cyclization suggest that this second electron oxidation step can be used to channel a reaction down new synthetic pathways. Here we describe one such application that reverses the normal reactivity of an imine group and sets the stage for the asymmetric synthesis of cyclic amines by anodic cyclization.
ISSN:1523-7060
1523-7052
DOI:10.1021/acs.orglett.3c01399