Eat, prey, love: Pathogen-mediated subversion of lysosomal biology

The mammalian lysosome is classically considered the 'garbage can' of the cell, contributing to clearance of infection through its primary function as a degradative organelle. Intracellular pathogens have evolved several strategies to evade contact with this harsh environment through subve...

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Bibliographic Details
Published in:Current opinion in immunology 2023-08, Vol.83, p.102344-102344, Article 102344
Main Authors: Bird, Lauren E, Edgington-Mitchell, Laura E, Newton, Hayley J
Format: Article
Language:English
Subjects:
Animals
Biology
Host-Pathogen Interactions
Humans
Love
Lysosomes
Mammals
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Summary:The mammalian lysosome is classically considered the 'garbage can' of the cell, contributing to clearance of infection through its primary function as a degradative organelle. Intracellular pathogens have evolved several strategies to evade contact with this harsh environment through subversion of endolysosomal trafficking or escape into the cytosol. Pathogens can also manipulate pathways that lead to lysosomal biogenesis or alter the abundance or activity of lysosomal content. This pathogen-driven subversion of lysosomal biology is highly dynamic and depends on a range of factors, including cell type, stage of infection, intracellular niche and pathogen load. The growing body of literature in this field highlights the nuanced and complex relationship between intracellular pathogens and the host lysosome, which is critical for our understanding of infection biology. •Pathogens utilise varied and complex strategies to evade lysosomal degradation.•Pathogen modulation of transcription factor EB (TFEB) is dynamic and multifactorial.•To alter lysosomal activity, pathogens can redirect lysosomal hydrolases.•Pathogens can impact non-canonical lysosomal functions such as cell death signalling.
ISSN:0952-7915
1879-0372
DOI:10.1016/j.coi.2023.102344