Cholesterol atlas of tumor microenvironment provides route to improved CAR-T therapy

Cholesterol is essential for the ability of cytotoxic T cells to eliminate cancer cells. In this issue of Cancer Cell, Yan et al. reveal how intra-tumoral cholesterol deficiency contributes to T cell exhaustion by inhibiting mTORC1 signaling. Moreover, they demonstrate that increasing cholesterol le...

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Bibliographic Details
Published in:Cancer cell 2023-07, Vol.41 (7), p.1204-1206
Main Authors: Chaves-Filho, Adriano B., Schulze, Almut
Format: Article
Language:English
Subjects:
Humans
Immunotherapy, Adoptive
Neoplasms - therapy
Receptors, Chimeric Antigen
T-Lymphocytes, Cytotoxic
Tumor Microenvironment
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Summary:Cholesterol is essential for the ability of cytotoxic T cells to eliminate cancer cells. In this issue of Cancer Cell, Yan et al. reveal how intra-tumoral cholesterol deficiency contributes to T cell exhaustion by inhibiting mTORC1 signaling. Moreover, they demonstrate that increasing cholesterol levels in chimeric antigen receptor (CAR)-T cells by blocking liver X receptor (LXR) leads to improved anti-tumor function. Cholesterol is essential for the ability of cytotoxic T cells to eliminate cancer cells. In this issue of Cancer Cell, Yan et al. reveal how intra-tumoral cholesterol deficiency contributes to T cell exhaustion by inhibiting mTORC1 signaling. Moreover, they demonstrate that increasing cholesterol levels in chimeric antigen receptor (CAR)-T cells by blocking liver X receptor (LXR) leads to improved anti-tumor function.
ISSN:1535-6108
1878-3686
DOI:10.1016/j.ccell.2023.05.013