Down regulation of the inverse relationship between parathyroid hormone and irisin in male vitamin D-sufficient HIV patients

Purpose Infection with the human immunodeficiency virus (HIV) predisposes to endocrine disorders, manifesting as a metabolic phenotype that affects the entire adipose-musculoskeletal unit (AMS). The present cross-sectional study aimed to investigate differences in irisin and adiponectin concentratio...

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Bibliographic Details
Published in:Journal of endocrinological investigation 2023-12, Vol.46 (12), p.2563-2571
Main Authors: Karras, S. N., Koufakis, T., Dimakopoulos, G., Zisimopoulou, E., Mourampetzis, P., Manthou, E., Karalazou, P., Thisiadou, K., Tsachouridou, O., Zebekakis, P., Makedou, K., Metallidis, S., Kotsa, K.
Format: Article
Language:English
Subjects:
25-Hydroxyvitamin D
Adiponectin
Anthropometry
Bone mineral density
Calcium homeostasis
Endocrine disorders
Endocrinology
HIV
Homeostasis
Human immunodeficiency virus
Internal Medicine
Medicine
Medicine & Public Health
Metabolic Diseases
Original Article
Parathyroid hormone
Phenotypes
Physical activity
Statistical analysis
Testosterone
Vitamin D
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Summary:Purpose Infection with the human immunodeficiency virus (HIV) predisposes to endocrine disorders, manifesting as a metabolic phenotype that affects the entire adipose-musculoskeletal unit (AMS). The present cross-sectional study aimed to investigate differences in irisin and adiponectin concentrations between people living with HIV and healthy controls, as well as to explore potential correlations between the levels of the aforementioned adipokines and markers of calcium homeostasis. Methods 46 HIV-infected individuals and 39 healthy controls (all men) were included in the study. Anthropometric data, adipokine levels, 25-hydroxyvitamin D [(25(OH)D)] and parathyroid hormone (PTH) concentrations were evaluated in the two groups. Correlations for the relationship between adiponectin, irisin, and PTH levels were examined. The results were adjusted for several confounders, including 25(OH)D levels, anthropometry, physical activity, bone mineral density, testosterone levels, and exposure to ultraviolet B radiation. Results Mean adiponectin concentrations were significantly lower in the HIV group compared to the control group: 5868 ± 3668 vs 9068 ± 4277 ng/mL, p  = 0.011. The same was applicable to irisin concentrations: 8.31 ± 8.17 (HIV) vs 29.27 ± 27.23 (controls) ng/mL, p  = 0.013. A statistically significant and negative correlation was observed between irisin and PTH in the control group ( r  =  – 0.591; p  = 0.033). In contrast, no significant correlation was observed between PTH and irisin in the HIV group ( p  = 0.898). Conclusion Our results are the first to suggest a possible down regulation of the inverse relationship between PTH and irisin in HIV patients and to highlight that AMS dyshomeostasis could be involved in the development of skeletal and adipose HIV-related morbidities.
ISSN:1720-8386
0391-4097
1720-8386
DOI:10.1007/s40618-023-02112-5