Testicular Rosai-Dorfman disease clonally related to CMML – Case report and literature review

Rosai-Dorfman disease (RDD), a rare form of non-Langerhans cell histiocytosis with heterogenous clinical features, arises from precursor cells that give rise to cells of the histiocytic and monocytic lineages. An association with hematological neoplasms has been reported. Testicular RDD is rarely de...

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Published in:Pathology, research and practice research and practice, 2023-07, Vol.247, p.154548-154548, Article 154548
Main Authors: Fiegl, August, Dirnhofer, Stefan, Juskevicius, Darius, Zagrapan, Branislav, Dertinger, Susanne, Bösl, Andreas, Milos, Stella, Brunner, Jürgen, Bertolini, Franz, Offner, Felix A.
Format: Article
Language:English
Subjects:
Case report
Chronic myelomonocytic leukemia
KRAS mutation
Rosai-Dorfman disease
Testis
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Summary:Rosai-Dorfman disease (RDD), a rare form of non-Langerhans cell histiocytosis with heterogenous clinical features, arises from precursor cells that give rise to cells of the histiocytic and monocytic lineages. An association with hematological neoplasms has been reported. Testicular RDD is rarely described, with only 9 reported cases in the literature. Genetic data to assess clonal relationships between RDD and other hematological neoplasms remain scarce. We describe an instance of testicular RDD against a background of chronic myelomonocytic leukemia (CMML), with genetic studies in both neoplasms. A 72-year-old patient with a history of CMML sought evaluation of growing bilateral testicular nodules. Solitary testicular lymphoma was suspected; orchidectomy was performed. The diagnosis of testicular RDD was established morphologically and confirmed immunohistochemically. Molecular analysis of testicular lesions and of archived patient bone marrow revealed the KRAS variant c 0.35 G>A / p.G12D in both, suggesting a clonal relationship. These observations support classifying RDD as a neoplasm that can be clonally related to myeloid neoplasms.
ISSN:0344-0338
1618-0631
DOI:10.1016/j.prp.2023.154548