Evaluation of pea/rice and amylopectin/chromium as an alternative protein source to improve muscle protein synthesis in rats

Background A preclinical study reported that the combination of an amylopectin/chromium complex (ACr) of branched-chain amino acids (BCAA) significantly enhanced muscle protein synthesis (MPS). This study was conducted to determine the effects of the addition of ACr complex to a pea/rice (PR) protei...

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Bibliographic Details
Published in:European journal of nutrition 2023-08, Vol.62 (5), p.2293-2302
Main Authors: Ozdemir, Oguzhan, Erten, Fusun, Er, Besir, Orhan, Cemal, Komorowski, James R., Sylla, Sarah, Perez Ojalvo, Sara, Sahin, Kazim
Format: Article
Language:English
Subjects:
Amylopectin
Amylopectin - metabolism
Amylopectin - pharmacology
Animals
Chemistry
Chemistry and Materials Science
Chromium
Humans
Insulin
Insulins - metabolism
Insulins - pharmacology
Muscle Proteins
Muscle, Skeletal - metabolism
Nutrition
Original Contribution
Oryza
Phosphorylation
Pisum sativum
Protein biosynthesis
Protein synthesis
Proteins
Rats
Rice
TOR protein
TOR Serine-Threonine Kinases - metabolism
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Summary:Background A preclinical study reported that the combination of an amylopectin/chromium complex (ACr) of branched-chain amino acids (BCAA) significantly enhanced muscle protein synthesis (MPS). This study was conducted to determine the effects of the addition of ACr complex to a pea/rice (PR) protein on MPS, insulin, muslin levels, and the mTOR pathway in exercised rats. Methods Twenty-four rats were divided into three groups: (i) exercise (Ex); (ii) Ex + PR 1:1 blend (0.465 g/kg BW); (iii) Ex + PR + ACr (0.155 g/kg BW). On the day of single-dose administration, after the animals were exercised at 26/m/min for 2 h, the supplement was given by oral gavage. The rats were injected with a bolus dose (250 mg/kg BW, 25 g/L) of deuterium-labeled phenylalanine to determine the protein fractional synthesis rate (FSR) one h after consuming the study product. Results The combination of PR and ACr enhanced MPS by 42.55% compared to the Ex group, while Ex + PR alone increased MPS by 30.2% over the Ex group ( p  
ISSN:1436-6207
1436-6215
DOI:10.1007/s00394-023-03150-8