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Direct synthesis of alkylated 4-hydroxycoumarin derivatives via a cascade Cu-catalyzed dehydrogenation/conjugate addition sequence
An efficient approach for the direct synthesis of alkylated 4-hydroxycoumarin derivatives a Cu-catalyzed cascade dehydrogenation/conjugate addition sequence starting from simple saturated ketones and 4-hydroxycoumarins has been developed. This protocol features excellent functional-group tolerance,...
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Published in: | Chemical communications (Cambridge, England) England), 2023-05, Vol.59 (44), p.6686-6689 |
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Main Authors: | , , , , |
Format: | Article |
Language: | English |
Subjects: | |
Citations: | Items that this one cites Items that cite this one |
Online Access: | Get full text |
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Summary: | An efficient approach for the direct synthesis of alkylated 4-hydroxycoumarin derivatives
a Cu-catalyzed cascade dehydrogenation/conjugate addition sequence starting from simple saturated ketones and 4-hydroxycoumarins has been developed. This protocol features excellent functional-group tolerance, easy scale-up, and a broad substrate scope including bioactive molecules. More importantly, a series of marketed drugs, such as warfarin, acenocoumarol, coumachlor, and coumafuryl, can be obtained by this method. |
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ISSN: | 1359-7345 1364-548X |
DOI: | 10.1039/d3cc01960h |