Activation of the aryl hydrocarbon receptor inhibits the development of experimental autoimmune pancreatitis through IL-22-mediated signaling pathways

Abstract The aryl hydrocarbon receptor (AhR) is a ligand-activated transcription factor expressed in hematopoietic and non-hematopoietic cells. Activation of the AhR by xenobiotics, microbial metabolites, and natural substances induces immunoregulatory responses. Autoimmune pancreatitis (AIP) is a c...

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Published in:Clinical and experimental immunology 2023-06, Vol.212 (3), p.171-183
Main Authors: Kamata, Ken, Hara, Akane, Minaga, Kosuke, Yoshikawa, Tomoe, Kurimoto, Masayuki, Sekai, Ikue, Okai, Natsuki, Omaru, Naoya, Masuta, Yasuhiro, Otsuka, Yasuo, Takada, Ryutaro, Takamura, Shiki, Kudo, Masatoshi, Strober, Warren, Watanabe, Tomohiro
Format: Article
Language:English
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Summary:Abstract The aryl hydrocarbon receptor (AhR) is a ligand-activated transcription factor expressed in hematopoietic and non-hematopoietic cells. Activation of the AhR by xenobiotics, microbial metabolites, and natural substances induces immunoregulatory responses. Autoimmune pancreatitis (AIP) is a chronic fibroinflammatory disorder of the pancreas driven by autoimmunity. Although AhR activation generally suppresses pathogenic autoimmune responses, the roles played by the AhR in AIP have been poorly defined. In this study, we examined how AhR activation affected the development of experimental AIP caused by the activation of plasmacytoid dendritic cells producing IFN-α and IL-33. Experimental AIP was induced in MRL/MpJ mice by repeated injections of polyinosinic-polycytidylic acid. Activation of the AhR by indole-3-pyruvic acid and indigo naturalis, which were supplemented in the diet, inhibited the development of experimental AIP, and these effects were independent of the activation of plasmacytoid dendritic cells producing IFN-α and IL-33. Interaction of indole-3-pyruvic acid and indigo naturalis with AhRs robustly augmented the production of IL-22 by pancreatic islet α cells. The blockade of IL-22 signaling pathways completely canceled the beneficial effects of AhR ligands on experimental AIP. Serum IL-22 concentrations were elevated in patients with type 1 AIP after the induction of remission with prednisolone. These data suggest that AhR activation suppresses chronic fibroinflammatory reactions that characterize AIP via IL-22 produced by pancreatic islet α cells. Indigo naturalis and dietary tryptophan rich in broccoli activate aryl hydrocarbon receptor (AhR). AhR activation inhibits the development of experimental autoimmune pancreatitis through IL-22 produced by pancreatic islet alpha cells. Graphical Abstract Graphical Abstract
ISSN:0009-9104
1365-2249
DOI:10.1093/cei/uxad040