Optical coherence tomography-based misdiagnosis and morphological distinction in pachychoroid neovasculopathy vs. polypoidal choroidal vasculopathy

To evaluate the rate of misdiagnosis of aneurysmatic pachychoroid type 1 choroidal neovascularization/polypoidal choroidal vasculopathy (PAT1/PCV) among cases diagnosed as non-aneurysmatic pachychoroid neovasculopathy (PNV) and to define optical coherence tomography (OCT) features facilitating their...

Full description

Saved in:
Bibliographic Details
Published in:Eye (London) 2023-11, Vol.37 (16), p.3435-3441
Main Authors: Siedlecki, Jakob, Klaas, Julian, Keidel, Leonie, Asani, Ben, Schiefelbein, Johannes, Knebel, Dominik, Luft, Nikolaus, Priglinger, Siegfried G, Schworm, Benedikt
Format: Article
Language:English
Subjects:
Aneurysms
Choroid
Choroidal Neovascularization - diagnosis
Diagnostic Errors
Fluorescein Angiography - methods
Humans
Medical imaging
Morphology
Ophthalmology
Polypoidal Choroidal Vasculopathy
Polyps
Retinal Detachment
Retrospective Studies
Statistical analysis
Tomography
Tomography, Optical Coherence - methods
Vascular diseases
Citations: Items that this one cites
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:To evaluate the rate of misdiagnosis of aneurysmatic pachychoroid type 1 choroidal neovascularization/polypoidal choroidal vasculopathy (PAT1/PCV) among cases diagnosed as non-aneurysmatic pachychoroid neovasculopathy (PNV) and to define optical coherence tomography (OCT) features facilitating their distinction. The database of the Department of Ophthalmology, Ludwig-Maximilians University Munich, was screened for patients diagnosed with PNV. Multimodal imaging was screened for the presence of choroidal neovascularization (CNV) and aneurysms/polyps. Imaging features facilitating the diagnosis of PAT1/PCV were analysed. In total, 49 eyes of 44 patients with a clinical PNV diagnosis were included, of which 42 (85.7%) had PNV and 7 (14.3%) represented misdiagnosed PAT1/PCV. SFCT was comparable (PNV: 377 ± 92 vs. PAT1/PCV: 400 ± 83 µm; p = 0.39). Whereas no difference was detected in total pigment epithelium detachment (PED) diameter (p = 0.46), maximum PED height was significantly higher in the PAT1/PCV group (199 ± 31 vs. 82 ± 46, p 
ISSN:0950-222X
1476-5454
DOI:10.1038/s41433-023-02529-5