Dimethylbutyrylated Dibenzocyclooctadiene Lignans from the Fruits of Schisandra cauliflora Inhibit NO Production in LPS‐Activated RAW264.7 Cells

From the fruits of Schisandra cauliflora, five new dimethylbutyrylated dibenzocyclooctadiene lignans, named schisandracaurins A−E, were isolated using separation and chromatographic techniques. Their structures were determined by extensive analyses of HR‐ESI‐MS, NMR, and ECD spectra. The schisandrac...

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Bibliographic Details
Published in:Chemistry & biodiversity 2023-06, Vol.20 (6), p.e202300372-n/a
Main Authors: Yen, Pham Hai, Hoang, Nguyen Huy, Nhiem, Nguyen Xuan, Thanh Huong, Phan Thi, Dung, Duong Thi, Cuc, Nguyen Thi, Cuong, Nguyen The, Thanh, Bui Van, Tai, Bui Huu, Kiem, Phan Van
Format: Article
Language:English
Subjects:
Chromatography
Cyclooctanes - analysis
Cyclooctanes - chemistry
Cyclooctanes - pharmacology
dimethylbutyrylated dibenzocyclooctadiene
Fruit - chemistry
Fruits
Lignans
Lignans - chemistry
Lipopolysaccharides - pharmacology
Molecular Structure
nitric oxide inhibitor
NMR
Nuclear magnetic resonance
Schisandra
Schisandra - chemistry
Schisandra cauliflora
schisandracaurin
Schisandraceae
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Summary:From the fruits of Schisandra cauliflora, five new dimethylbutyrylated dibenzocyclooctadiene lignans, named schisandracaurins A−E, were isolated using separation and chromatographic techniques. Their structures were determined by extensive analyses of HR‐ESI‐MS, NMR, and ECD spectra. The schisandracaurins A−E potentially inhibited NO production in LPS‐activated RAW264.7 cells with their IC50 values from 21.4 to 30.3 μM.
ISSN:1612-1872
1612-1880
DOI:10.1002/cbdv.202300372