The emergence of multi-drug-resistant bacteria causing healthcare-associated infections in COVID-19 patients: a retrospective multi-centre study

We evaluated the prevalence, aetiologies and antibiotic resistance patterns of bacterial infections in hospitalized patients with laboratory-confirmed SARS-CoV-2. We also investigated comorbidities, risk factors and the mortality rate in COVID-19 patients with bacterial infections. This retrospectiv...

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Bibliographic Details
Published in:The Journal of hospital infection 2023-07, Vol.137, p.1-7
Main Authors: Gajic, I., Jovicevic, M., Popadic, V., Trudic, A., Kabic, J., Kekic, D., Ilic, A., Klasnja, S., Hadnadjev, M., Popadic, D.J., Andrijevic, A., Prokic, A., Tomasevic, R., Ranin, L., Todorovic, Z., Zdravkovic, M., Opavski, N.
Format: Article
Language:English
Subjects:
Antimicrobial resistance
Bacterial infections
COVID-19
SARS-CoV-2
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Summary:We evaluated the prevalence, aetiologies and antibiotic resistance patterns of bacterial infections in hospitalized patients with laboratory-confirmed SARS-CoV-2. We also investigated comorbidities, risk factors and the mortality rate in COVID-19 patients with bacterial infections. This retrospective observational study evaluated medical records of 7249 randomly selected patients with COVID-19 admitted to three clinical centres between 1st January 2021 and 16th February 2022. A total of 6478 COVID-19 patients met the eligibility criteria for analysis. The mean age of the patients with SARS-CoV-2 and bacterial infections was 68.6 ± 15.5 years (range: 24–94 years). The majority of patients (68.7%) were older than 65 years. The prevalence of bacterial infections among hospitalized COVID-19 patients was 12.9%, most of them being hospital-acquired (11.5%). Bloodstream (37.7%) and respiratory tract infections (25.6%) were the most common bacterial infections. Klebsiella pneumoniae and Acinetobacter baumannii caused 25.2% and 23.6% of all bacterial infections, respectively. Carbapenem-resistance in Enterobacterales, A. baumannii and Pseudomonas aeruginosa were 71.3%, 93.8% and 69.1%, respectively. Age >60 years and infections caused by ≥3 pathogens were significantly more prevalent among deceased patients compared with survivors (P
ISSN:0195-6701
1532-2939
DOI:10.1016/j.jhin.2023.04.013