Optimization of topical curcumin spanlastics for melanoma treatment

The aim of the study was to enhance curcumin skin permeability through the preparation of spanlastics. Spanlastics were prepared using the ethanol injection technique through a central composite design using Span 60 concentration (X 1 ), edge activator type (X 2 ), and its concentration (X 3 ) as th...

Full description

Saved in:
Bibliographic Details
Published in:Pharmaceutical development and technology 2023-05, Vol.28 (5), p.425-439
Main Authors: Ismail, Soha, Garhy, Doaa, Ibrahim, Howida K.
Format: Article
Language:English
Subjects:
apoptosis
Curcumin
Curcumin - pharmacology
Drug Carriers - metabolism
Drug Delivery Systems - methods
Humans
melanoma
Melanoma - drug therapy
Particle Size
permeability
Skin - metabolism
Skin Absorption
spanlastics
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The aim of the study was to enhance curcumin skin permeability through the preparation of spanlastics. Spanlastics were prepared using the ethanol injection technique through a central composite design using Span 60 concentration (X 1 ), edge activator type (X 2 ), and its concentration (X 3 ) as the independent variables. The spanlastics were characterized for particle size (PS), encapsulation efficiency (EE), and dissolution efficiency (%DE 24h ). Formulae with the highest desirability (FN1 and FN2) were prepared and further characterized. They were elastic, spherical, nonirritant, and compatible with the used excipients. They had particle sizes of 147 and 198 nm, encapsulation efficiencies of 84.00% and 89.63%, zeta potential values of −45.50 and −39.10 mV, permeation enhancement ratios of 11.51 and 8.34 folds, and amounts retained of 7.25 and 10.44 µg/cm 2 after 24 h, respectively. Formulae FN1 and FN2 showed cytotoxic effects after 48 h on human melanoma A375 with IC50 of 10.9 and 75.6 μg/mL, respectively. They increased the apoptotic effect confirming the success of the spanlastics to be a potential delivery for melanoma treatment.
ISSN:1083-7450
1097-9867
DOI:10.1080/10837450.2023.2204926