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Pathogens identified in the internal tissues and placentas of stillbirths: results from the prospective, observational PURPOSe study
Objective To examine internal organ tissues and placentas of stillbirths for various pathogens. Design Prospective, observational study. Settings Three study hospitals in India and a large maternity hospital in Pakistan. Population Stillborn infants delivered in a study hospital. Methods A prospecti...
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| Published in: | BJOG : an international journal of obstetrics and gynaecology 2023-09, Vol.130 (10), p.1238-1246 |
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| Main Authors: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
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| container_title | BJOG : an international journal of obstetrics and gynaecology |
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| creator | Harakuni, Sheetal U. Somannavar, Manjunath S. Ghanchi, Najia K. Ahmed, Imran Zafar, Afia Kim, Jean Tikmani, Shiyam Sunder Hwang, Kay Saleem, Sarah Goudar, Shivaprasad S. Dhaded, Sangappa Guruprasad, Gowder Yasmin, Haleema Yogeshkumar, S. Aceituno, Anna Silver, Robert M. McClure, Elizabeth M. Goldenberg, R. L. Nagmoti, Mahantesh B Yogesh Kumar, S Aradhya, Gayathri H Nadig, Naveen Kusgur, Varun Raghoji, Chaitali R Siddartha, ES Patil, Lingaraja Gowda C Pujar, Sneharoopa Dhananjaya, Shobha Sarvamangala, B Prakash, Veena Mangala, G K Rajashekhar, K S Sunilkumar, K Byranahalli Kulkarni, Vardendra Nagaraj, T S Jeevika, M U Joish, Upendra Kumar Harikiran, Reddy R Uddin, Zeeshan Ariff, Shabina Roujani, Sana Reza, Sayyeda Yasmin, Haleema Bano, Khadija Raza, Jamal Parkash, Jai Parlberg, Lindsay Moore, Janet L Parepelli, Suchita Bann, Carla |
| description | Objective
To examine internal organ tissues and placentas of stillbirths for various pathogens.
Design
Prospective, observational study.
Settings
Three study hospitals in India and a large maternity hospital in Pakistan.
Population
Stillborn infants delivered in a study hospital.
Methods
A prospective observational study.
Main outcome measures
Organisms identified by pathogen polymerase chain reaction (PCR) in internal organs and placental tissues of stillbirths.
Results
Of 2437 stillbirth internal tissues, 8.3% (95% CI 7.2–9.4) were positive. Organisms were most commonly detected in brain (12.3%), cerebrospinal fluid (CSF) (9.5%) and whole blood (8.4%). Ureaplasma urealyticum/parvum was the organism most frequently detected in at least one internal organ (6.4% of stillbirths and 2% of all tissues). Escherichia coli/Shigella was the next most common (4.1% one or more internal organ tissue sample and 1.3% of tissue samples), followed by Staphylococcus aureus in at least one internal organ tissue (1.9% and 0.9% of all tissues). None of the other organisms was found in more than 1.4% of the tissue samples in stillbirths or more than 0.6% of the internal tissues examined. In the placenta tissue, membrane or cord blood combined, 42.8% (95% CI 40.2–45.3) had at least one organism identified, with U. urealyticum/parvum representing the most commonly identified (27.8%).
Conclusions
In about 8% of stillbirths, there was evidence of a pathogen in an internal organ. Ureaplasma urealyticum/parvum was the most common organism found in the placenta and in the internal tissues, especially in the fetal brain. |
| doi_str_mv | 10.1111/1471-0528.17479 |
| format | article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2802885352</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2844394690</sourcerecordid><originalsourceid>FETCH-LOGICAL-c3259-494aaacce7ff9abc6cddbe2d07fd91bdb4f7d0d9868efd2f624f755c2ef0cc873</originalsourceid><addsrcrecordid>eNqFkUtuFDEQhi1ERB6wZocssWGRTmz3w212EEEgijQjIOuW2y4zjjzdg8sdNAfgHpyFk8U9E7Jggzdllb765PJPyEvOzng-57ySvGC1aM-4rKR6Qo4eO093d1awUrSH5BjxljHeCFY-I4elZI2SJT8iv5Y6rcbvMCD1FobknQdL_UDTCnJJEAcdaPKIEyDVg6WboE0GNdLRUUw-hN7HtMK3NAJOISF1cVzv5jdxxA2Y5O_glI49QrzTyY-zcXnzZbn4Cn9-Y5rs9jk5cDogvHioJ-Tm44dvF5-K68Xl54t314UpRa2KSlVaa2NAOqd0bxpjbQ_CMums4r3tKycts6ptWnBWuEbkRl0bAY4Z08ryhLzZe_PLfuSFUrf2aCAEPcA4YSdaJtq2LmuR0df_oLfjNH_GTFVVqapGsUyd7ymTV8UIrttEv9Zx23HWzQl1cx7dnEe3SyhPvHrwTv0a7CP_N5IM1Hvgpw-w_Z-ve3-12IvvAfhanz0</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2844394690</pqid></control><display><type>article</type><title>Pathogens identified in the internal tissues and placentas of stillbirths: results from the prospective, observational PURPOSe study</title><source>Wiley</source><creator>Harakuni, Sheetal U. ; Somannavar, Manjunath S. ; Ghanchi, Najia K. ; Ahmed, Imran ; Zafar, Afia ; Kim, Jean ; Tikmani, Shiyam Sunder ; Hwang, Kay ; Saleem, Sarah ; Goudar, Shivaprasad S. ; Dhaded, Sangappa ; Guruprasad, Gowder ; Yasmin, Haleema ; Yogeshkumar, S. ; Aceituno, Anna ; Silver, Robert M. ; McClure, Elizabeth M. ; Goldenberg, R. L. ; Nagmoti, Mahantesh B ; Yogesh Kumar, S ; Aradhya, Gayathri H ; Nadig, Naveen ; Kusgur, Varun ; Raghoji, Chaitali R ; Siddartha, ES ; Patil, Lingaraja Gowda C ; Pujar, Sneharoopa ; Dhananjaya, Shobha ; Sarvamangala, B ; Prakash, Veena ; Mangala, G K ; Rajashekhar, K S ; Sunilkumar, K Byranahalli ; Kulkarni, Vardendra ; Nagaraj, T S ; Jeevika, M U ; Joish, Upendra Kumar ; Harikiran, Reddy R ; Uddin, Zeeshan ; Ariff, Shabina ; Roujani, Sana ; Reza, Sayyeda ; Yasmin, Haleema ; Bano, Khadija ; Raza, Jamal ; Parkash, Jai ; Parlberg, Lindsay ; Moore, Janet L ; Parepelli, Suchita ; Bann, Carla</creator><creatorcontrib>Harakuni, Sheetal U. ; Somannavar, Manjunath S. ; Ghanchi, Najia K. ; Ahmed, Imran ; Zafar, Afia ; Kim, Jean ; Tikmani, Shiyam Sunder ; Hwang, Kay ; Saleem, Sarah ; Goudar, Shivaprasad S. ; Dhaded, Sangappa ; Guruprasad, Gowder ; Yasmin, Haleema ; Yogeshkumar, S. ; Aceituno, Anna ; Silver, Robert M. ; McClure, Elizabeth M. ; Goldenberg, R. L. ; Nagmoti, Mahantesh B ; Yogesh Kumar, S ; Aradhya, Gayathri H ; Nadig, Naveen ; Kusgur, Varun ; Raghoji, Chaitali R ; Siddartha, ES ; Patil, Lingaraja Gowda C ; Pujar, Sneharoopa ; Dhananjaya, Shobha ; Sarvamangala, B ; Prakash, Veena ; Mangala, G K ; Rajashekhar, K S ; Sunilkumar, K Byranahalli ; Kulkarni, Vardendra ; Nagaraj, T S ; Jeevika, M U ; Joish, Upendra Kumar ; Harikiran, Reddy R ; Uddin, Zeeshan ; Ariff, Shabina ; Roujani, Sana ; Reza, Sayyeda ; Yasmin, Haleema ; Bano, Khadija ; Raza, Jamal ; Parkash, Jai ; Parlberg, Lindsay ; Moore, Janet L ; Parepelli, Suchita ; Bann, Carla ; PURPOSe Investigators ; the PURPOSe Investigators</creatorcontrib><description>Objective
To examine internal organ tissues and placentas of stillbirths for various pathogens.
Design
Prospective, observational study.
Settings
Three study hospitals in India and a large maternity hospital in Pakistan.
Population
Stillborn infants delivered in a study hospital.
Methods
A prospective observational study.
Main outcome measures
Organisms identified by pathogen polymerase chain reaction (PCR) in internal organs and placental tissues of stillbirths.
Results
Of 2437 stillbirth internal tissues, 8.3% (95% CI 7.2–9.4) were positive. Organisms were most commonly detected in brain (12.3%), cerebrospinal fluid (CSF) (9.5%) and whole blood (8.4%). Ureaplasma urealyticum/parvum was the organism most frequently detected in at least one internal organ (6.4% of stillbirths and 2% of all tissues). Escherichia coli/Shigella was the next most common (4.1% one or more internal organ tissue sample and 1.3% of tissue samples), followed by Staphylococcus aureus in at least one internal organ tissue (1.9% and 0.9% of all tissues). None of the other organisms was found in more than 1.4% of the tissue samples in stillbirths or more than 0.6% of the internal tissues examined. In the placenta tissue, membrane or cord blood combined, 42.8% (95% CI 40.2–45.3) had at least one organism identified, with U. urealyticum/parvum representing the most commonly identified (27.8%).
Conclusions
In about 8% of stillbirths, there was evidence of a pathogen in an internal organ. Ureaplasma urealyticum/parvum was the most common organism found in the placenta and in the internal tissues, especially in the fetal brain.</description><identifier>ISSN: 1470-0328</identifier><identifier>EISSN: 1471-0528</identifier><identifier>DOI: 10.1111/1471-0528.17479</identifier><identifier>PMID: 37069731</identifier><language>eng</language><publisher>England: Wiley Subscription Services, Inc</publisher><subject>Cerebrospinal fluid ; Cord blood ; Fetuses ; India ; infection ; minimall invasive tissue sampling ; Observational studies ; Organisms ; Pakistan ; Pathogens ; PCR ; Placenta ; Polymerase chain reaction ; stillbirth ; Ureaplasma urealyticum</subject><ispartof>BJOG : an international journal of obstetrics and gynaecology, 2023-09, Vol.130 (10), p.1238-1246</ispartof><rights>2023 John Wiley & Sons Ltd.</rights><rights>Copyright © 2023 Royal College of Obstetricians and Gynaecologists</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c3259-494aaacce7ff9abc6cddbe2d07fd91bdb4f7d0d9868efd2f624f755c2ef0cc873</cites><orcidid>0000-0001-8659-5444</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2F1471-0528.17479$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2F1471-0528.17479$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>315,786,790,27957,27958,50923,51032</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/37069731$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Harakuni, Sheetal U.</creatorcontrib><creatorcontrib>Somannavar, Manjunath S.</creatorcontrib><creatorcontrib>Ghanchi, Najia K.</creatorcontrib><creatorcontrib>Ahmed, Imran</creatorcontrib><creatorcontrib>Zafar, Afia</creatorcontrib><creatorcontrib>Kim, Jean</creatorcontrib><creatorcontrib>Tikmani, Shiyam Sunder</creatorcontrib><creatorcontrib>Hwang, Kay</creatorcontrib><creatorcontrib>Saleem, Sarah</creatorcontrib><creatorcontrib>Goudar, Shivaprasad S.</creatorcontrib><creatorcontrib>Dhaded, Sangappa</creatorcontrib><creatorcontrib>Guruprasad, Gowder</creatorcontrib><creatorcontrib>Yasmin, Haleema</creatorcontrib><creatorcontrib>Yogeshkumar, S.</creatorcontrib><creatorcontrib>Aceituno, Anna</creatorcontrib><creatorcontrib>Silver, Robert M.</creatorcontrib><creatorcontrib>McClure, Elizabeth M.</creatorcontrib><creatorcontrib>Goldenberg, R. L.</creatorcontrib><creatorcontrib>Nagmoti, Mahantesh B</creatorcontrib><creatorcontrib>Yogesh Kumar, S</creatorcontrib><creatorcontrib>Aradhya, Gayathri H</creatorcontrib><creatorcontrib>Nadig, Naveen</creatorcontrib><creatorcontrib>Kusgur, Varun</creatorcontrib><creatorcontrib>Raghoji, Chaitali R</creatorcontrib><creatorcontrib>Siddartha, ES</creatorcontrib><creatorcontrib>Patil, Lingaraja Gowda C</creatorcontrib><creatorcontrib>Pujar, Sneharoopa</creatorcontrib><creatorcontrib>Dhananjaya, Shobha</creatorcontrib><creatorcontrib>Sarvamangala, B</creatorcontrib><creatorcontrib>Prakash, Veena</creatorcontrib><creatorcontrib>Mangala, G K</creatorcontrib><creatorcontrib>Rajashekhar, K S</creatorcontrib><creatorcontrib>Sunilkumar, K Byranahalli</creatorcontrib><creatorcontrib>Kulkarni, Vardendra</creatorcontrib><creatorcontrib>Nagaraj, T S</creatorcontrib><creatorcontrib>Jeevika, M U</creatorcontrib><creatorcontrib>Joish, Upendra Kumar</creatorcontrib><creatorcontrib>Harikiran, Reddy R</creatorcontrib><creatorcontrib>Uddin, Zeeshan</creatorcontrib><creatorcontrib>Ariff, Shabina</creatorcontrib><creatorcontrib>Roujani, Sana</creatorcontrib><creatorcontrib>Reza, Sayyeda</creatorcontrib><creatorcontrib>Yasmin, Haleema</creatorcontrib><creatorcontrib>Bano, Khadija</creatorcontrib><creatorcontrib>Raza, Jamal</creatorcontrib><creatorcontrib>Parkash, Jai</creatorcontrib><creatorcontrib>Parlberg, Lindsay</creatorcontrib><creatorcontrib>Moore, Janet L</creatorcontrib><creatorcontrib>Parepelli, Suchita</creatorcontrib><creatorcontrib>Bann, Carla</creatorcontrib><creatorcontrib>PURPOSe Investigators</creatorcontrib><creatorcontrib>the PURPOSe Investigators</creatorcontrib><title>Pathogens identified in the internal tissues and placentas of stillbirths: results from the prospective, observational PURPOSe study</title><title>BJOG : an international journal of obstetrics and gynaecology</title><addtitle>BJOG</addtitle><description>Objective
To examine internal organ tissues and placentas of stillbirths for various pathogens.
Design
Prospective, observational study.
Settings
Three study hospitals in India and a large maternity hospital in Pakistan.
Population
Stillborn infants delivered in a study hospital.
Methods
A prospective observational study.
Main outcome measures
Organisms identified by pathogen polymerase chain reaction (PCR) in internal organs and placental tissues of stillbirths.
Results
Of 2437 stillbirth internal tissues, 8.3% (95% CI 7.2–9.4) were positive. Organisms were most commonly detected in brain (12.3%), cerebrospinal fluid (CSF) (9.5%) and whole blood (8.4%). Ureaplasma urealyticum/parvum was the organism most frequently detected in at least one internal organ (6.4% of stillbirths and 2% of all tissues). Escherichia coli/Shigella was the next most common (4.1% one or more internal organ tissue sample and 1.3% of tissue samples), followed by Staphylococcus aureus in at least one internal organ tissue (1.9% and 0.9% of all tissues). None of the other organisms was found in more than 1.4% of the tissue samples in stillbirths or more than 0.6% of the internal tissues examined. In the placenta tissue, membrane or cord blood combined, 42.8% (95% CI 40.2–45.3) had at least one organism identified, with U. urealyticum/parvum representing the most commonly identified (27.8%).
Conclusions
In about 8% of stillbirths, there was evidence of a pathogen in an internal organ. Ureaplasma urealyticum/parvum was the most common organism found in the placenta and in the internal tissues, especially in the fetal brain.</description><subject>Cerebrospinal fluid</subject><subject>Cord blood</subject><subject>Fetuses</subject><subject>India</subject><subject>infection</subject><subject>minimall invasive tissue sampling</subject><subject>Observational studies</subject><subject>Organisms</subject><subject>Pakistan</subject><subject>Pathogens</subject><subject>PCR</subject><subject>Placenta</subject><subject>Polymerase chain reaction</subject><subject>stillbirth</subject><subject>Ureaplasma urealyticum</subject><issn>1470-0328</issn><issn>1471-0528</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><recordid>eNqFkUtuFDEQhi1ERB6wZocssWGRTmz3w212EEEgijQjIOuW2y4zjjzdg8sdNAfgHpyFk8U9E7Jggzdllb765PJPyEvOzng-57ySvGC1aM-4rKR6Qo4eO093d1awUrSH5BjxljHeCFY-I4elZI2SJT8iv5Y6rcbvMCD1FobknQdL_UDTCnJJEAcdaPKIEyDVg6WboE0GNdLRUUw-hN7HtMK3NAJOISF1cVzv5jdxxA2Y5O_glI49QrzTyY-zcXnzZbn4Cn9-Y5rs9jk5cDogvHioJ-Tm44dvF5-K68Xl54t314UpRa2KSlVaa2NAOqd0bxpjbQ_CMums4r3tKycts6ptWnBWuEbkRl0bAY4Z08ryhLzZe_PLfuSFUrf2aCAEPcA4YSdaJtq2LmuR0df_oLfjNH_GTFVVqapGsUyd7ymTV8UIrttEv9Zx23HWzQl1cx7dnEe3SyhPvHrwTv0a7CP_N5IM1Hvgpw-w_Z-ve3-12IvvAfhanz0</recordid><startdate>202309</startdate><enddate>202309</enddate><creator>Harakuni, Sheetal U.</creator><creator>Somannavar, Manjunath S.</creator><creator>Ghanchi, Najia K.</creator><creator>Ahmed, Imran</creator><creator>Zafar, Afia</creator><creator>Kim, Jean</creator><creator>Tikmani, Shiyam Sunder</creator><creator>Hwang, Kay</creator><creator>Saleem, Sarah</creator><creator>Goudar, Shivaprasad S.</creator><creator>Dhaded, Sangappa</creator><creator>Guruprasad, Gowder</creator><creator>Yasmin, Haleema</creator><creator>Yogeshkumar, S.</creator><creator>Aceituno, Anna</creator><creator>Silver, Robert M.</creator><creator>McClure, Elizabeth M.</creator><creator>Goldenberg, R. L.</creator><creator>Nagmoti, Mahantesh B</creator><creator>Yogesh Kumar, S</creator><creator>Aradhya, Gayathri H</creator><creator>Nadig, Naveen</creator><creator>Kusgur, Varun</creator><creator>Raghoji, Chaitali R</creator><creator>Siddartha, ES</creator><creator>Patil, Lingaraja Gowda C</creator><creator>Pujar, Sneharoopa</creator><creator>Dhananjaya, Shobha</creator><creator>Sarvamangala, B</creator><creator>Prakash, Veena</creator><creator>Mangala, G K</creator><creator>Rajashekhar, K S</creator><creator>Sunilkumar, K Byranahalli</creator><creator>Kulkarni, Vardendra</creator><creator>Nagaraj, T S</creator><creator>Jeevika, M U</creator><creator>Joish, Upendra Kumar</creator><creator>Harikiran, Reddy R</creator><creator>Uddin, Zeeshan</creator><creator>Ariff, Shabina</creator><creator>Roujani, Sana</creator><creator>Reza, Sayyeda</creator><creator>Yasmin, Haleema</creator><creator>Bano, Khadija</creator><creator>Raza, Jamal</creator><creator>Parkash, Jai</creator><creator>Parlberg, Lindsay</creator><creator>Moore, Janet L</creator><creator>Parepelli, Suchita</creator><creator>Bann, Carla</creator><general>Wiley Subscription Services, Inc</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>ASE</scope><scope>FPQ</scope><scope>K6X</scope><scope>K9.</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0001-8659-5444</orcidid></search><sort><creationdate>202309</creationdate><title>Pathogens identified in the internal tissues and placentas of stillbirths: results from the prospective, observational PURPOSe study</title><author>Harakuni, Sheetal U. ; Somannavar, Manjunath S. ; Ghanchi, Najia K. ; Ahmed, Imran ; Zafar, Afia ; Kim, Jean ; Tikmani, Shiyam Sunder ; Hwang, Kay ; Saleem, Sarah ; Goudar, Shivaprasad S. ; Dhaded, Sangappa ; Guruprasad, Gowder ; Yasmin, Haleema ; Yogeshkumar, S. ; Aceituno, Anna ; Silver, Robert M. ; McClure, Elizabeth M. ; Goldenberg, R. L. ; Nagmoti, Mahantesh B ; Yogesh Kumar, S ; Aradhya, Gayathri H ; Nadig, Naveen ; Kusgur, Varun ; Raghoji, Chaitali R ; Siddartha, ES ; Patil, Lingaraja Gowda C ; Pujar, Sneharoopa ; Dhananjaya, Shobha ; Sarvamangala, B ; Prakash, Veena ; Mangala, G K ; Rajashekhar, K S ; Sunilkumar, K Byranahalli ; Kulkarni, Vardendra ; Nagaraj, T S ; Jeevika, M U ; Joish, Upendra Kumar ; Harikiran, Reddy R ; Uddin, Zeeshan ; Ariff, Shabina ; Roujani, Sana ; Reza, Sayyeda ; Yasmin, Haleema ; Bano, Khadija ; Raza, Jamal ; Parkash, Jai ; Parlberg, Lindsay ; Moore, Janet L ; Parepelli, Suchita ; Bann, Carla</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3259-494aaacce7ff9abc6cddbe2d07fd91bdb4f7d0d9868efd2f624f755c2ef0cc873</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Cerebrospinal fluid</topic><topic>Cord blood</topic><topic>Fetuses</topic><topic>India</topic><topic>infection</topic><topic>minimall invasive tissue sampling</topic><topic>Observational studies</topic><topic>Organisms</topic><topic>Pakistan</topic><topic>Pathogens</topic><topic>PCR</topic><topic>Placenta</topic><topic>Polymerase chain reaction</topic><topic>stillbirth</topic><topic>Ureaplasma urealyticum</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Harakuni, Sheetal U.</creatorcontrib><creatorcontrib>Somannavar, Manjunath S.</creatorcontrib><creatorcontrib>Ghanchi, Najia K.</creatorcontrib><creatorcontrib>Ahmed, Imran</creatorcontrib><creatorcontrib>Zafar, Afia</creatorcontrib><creatorcontrib>Kim, Jean</creatorcontrib><creatorcontrib>Tikmani, Shiyam Sunder</creatorcontrib><creatorcontrib>Hwang, Kay</creatorcontrib><creatorcontrib>Saleem, Sarah</creatorcontrib><creatorcontrib>Goudar, Shivaprasad S.</creatorcontrib><creatorcontrib>Dhaded, Sangappa</creatorcontrib><creatorcontrib>Guruprasad, Gowder</creatorcontrib><creatorcontrib>Yasmin, Haleema</creatorcontrib><creatorcontrib>Yogeshkumar, S.</creatorcontrib><creatorcontrib>Aceituno, Anna</creatorcontrib><creatorcontrib>Silver, Robert M.</creatorcontrib><creatorcontrib>McClure, Elizabeth M.</creatorcontrib><creatorcontrib>Goldenberg, R. L.</creatorcontrib><creatorcontrib>Nagmoti, Mahantesh B</creatorcontrib><creatorcontrib>Yogesh Kumar, S</creatorcontrib><creatorcontrib>Aradhya, Gayathri H</creatorcontrib><creatorcontrib>Nadig, Naveen</creatorcontrib><creatorcontrib>Kusgur, Varun</creatorcontrib><creatorcontrib>Raghoji, Chaitali R</creatorcontrib><creatorcontrib>Siddartha, ES</creatorcontrib><creatorcontrib>Patil, Lingaraja Gowda C</creatorcontrib><creatorcontrib>Pujar, Sneharoopa</creatorcontrib><creatorcontrib>Dhananjaya, Shobha</creatorcontrib><creatorcontrib>Sarvamangala, B</creatorcontrib><creatorcontrib>Prakash, Veena</creatorcontrib><creatorcontrib>Mangala, G K</creatorcontrib><creatorcontrib>Rajashekhar, K S</creatorcontrib><creatorcontrib>Sunilkumar, K Byranahalli</creatorcontrib><creatorcontrib>Kulkarni, Vardendra</creatorcontrib><creatorcontrib>Nagaraj, T S</creatorcontrib><creatorcontrib>Jeevika, M U</creatorcontrib><creatorcontrib>Joish, Upendra Kumar</creatorcontrib><creatorcontrib>Harikiran, Reddy R</creatorcontrib><creatorcontrib>Uddin, Zeeshan</creatorcontrib><creatorcontrib>Ariff, Shabina</creatorcontrib><creatorcontrib>Roujani, Sana</creatorcontrib><creatorcontrib>Reza, Sayyeda</creatorcontrib><creatorcontrib>Yasmin, Haleema</creatorcontrib><creatorcontrib>Bano, Khadija</creatorcontrib><creatorcontrib>Raza, Jamal</creatorcontrib><creatorcontrib>Parkash, Jai</creatorcontrib><creatorcontrib>Parlberg, Lindsay</creatorcontrib><creatorcontrib>Moore, Janet L</creatorcontrib><creatorcontrib>Parepelli, Suchita</creatorcontrib><creatorcontrib>Bann, Carla</creatorcontrib><creatorcontrib>PURPOSe Investigators</creatorcontrib><creatorcontrib>the PURPOSe Investigators</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>British Nursing Index</collection><collection>British Nursing Index (BNI) (1985 to Present)</collection><collection>British Nursing Index</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>BJOG : an international journal of obstetrics and gynaecology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Harakuni, Sheetal U.</au><au>Somannavar, Manjunath S.</au><au>Ghanchi, Najia K.</au><au>Ahmed, Imran</au><au>Zafar, Afia</au><au>Kim, Jean</au><au>Tikmani, Shiyam Sunder</au><au>Hwang, Kay</au><au>Saleem, Sarah</au><au>Goudar, Shivaprasad S.</au><au>Dhaded, Sangappa</au><au>Guruprasad, Gowder</au><au>Yasmin, Haleema</au><au>Yogeshkumar, S.</au><au>Aceituno, Anna</au><au>Silver, Robert M.</au><au>McClure, Elizabeth M.</au><au>Goldenberg, R. L.</au><au>Nagmoti, Mahantesh B</au><au>Yogesh Kumar, S</au><au>Aradhya, Gayathri H</au><au>Nadig, Naveen</au><au>Kusgur, Varun</au><au>Raghoji, Chaitali R</au><au>Siddartha, ES</au><au>Patil, Lingaraja Gowda C</au><au>Pujar, Sneharoopa</au><au>Dhananjaya, Shobha</au><au>Sarvamangala, B</au><au>Prakash, Veena</au><au>Mangala, G K</au><au>Rajashekhar, K S</au><au>Sunilkumar, K Byranahalli</au><au>Kulkarni, Vardendra</au><au>Nagaraj, T S</au><au>Jeevika, M U</au><au>Joish, Upendra Kumar</au><au>Harikiran, Reddy R</au><au>Uddin, Zeeshan</au><au>Ariff, Shabina</au><au>Roujani, Sana</au><au>Reza, Sayyeda</au><au>Yasmin, Haleema</au><au>Bano, Khadija</au><au>Raza, Jamal</au><au>Parkash, Jai</au><au>Parlberg, Lindsay</au><au>Moore, Janet L</au><au>Parepelli, Suchita</au><au>Bann, Carla</au><aucorp>PURPOSe Investigators</aucorp><aucorp>the PURPOSe Investigators</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Pathogens identified in the internal tissues and placentas of stillbirths: results from the prospective, observational PURPOSe study</atitle><jtitle>BJOG : an international journal of obstetrics and gynaecology</jtitle><addtitle>BJOG</addtitle><date>2023-09</date><risdate>2023</risdate><volume>130</volume><issue>10</issue><spage>1238</spage><epage>1246</epage><pages>1238-1246</pages><issn>1470-0328</issn><eissn>1471-0528</eissn><notes>ObjectType-Article-1</notes><notes>SourceType-Scholarly Journals-1</notes><notes>ObjectType-Feature-2</notes><notes>content type line 23</notes><notes>ObjectType-Undefined-3</notes><abstract>Objective
To examine internal organ tissues and placentas of stillbirths for various pathogens.
Design
Prospective, observational study.
Settings
Three study hospitals in India and a large maternity hospital in Pakistan.
Population
Stillborn infants delivered in a study hospital.
Methods
A prospective observational study.
Main outcome measures
Organisms identified by pathogen polymerase chain reaction (PCR) in internal organs and placental tissues of stillbirths.
Results
Of 2437 stillbirth internal tissues, 8.3% (95% CI 7.2–9.4) were positive. Organisms were most commonly detected in brain (12.3%), cerebrospinal fluid (CSF) (9.5%) and whole blood (8.4%). Ureaplasma urealyticum/parvum was the organism most frequently detected in at least one internal organ (6.4% of stillbirths and 2% of all tissues). Escherichia coli/Shigella was the next most common (4.1% one or more internal organ tissue sample and 1.3% of tissue samples), followed by Staphylococcus aureus in at least one internal organ tissue (1.9% and 0.9% of all tissues). None of the other organisms was found in more than 1.4% of the tissue samples in stillbirths or more than 0.6% of the internal tissues examined. In the placenta tissue, membrane or cord blood combined, 42.8% (95% CI 40.2–45.3) had at least one organism identified, with U. urealyticum/parvum representing the most commonly identified (27.8%).
Conclusions
In about 8% of stillbirths, there was evidence of a pathogen in an internal organ. Ureaplasma urealyticum/parvum was the most common organism found in the placenta and in the internal tissues, especially in the fetal brain.</abstract><cop>England</cop><pub>Wiley Subscription Services, Inc</pub><pmid>37069731</pmid><doi>10.1111/1471-0528.17479</doi><tpages>9</tpages><orcidid>https://orcid.org/0000-0001-8659-5444</orcidid></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1470-0328 |
| ispartof | BJOG : an international journal of obstetrics and gynaecology, 2023-09, Vol.130 (10), p.1238-1246 |
| issn | 1470-0328 1471-0528 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_2802885352 |
| source | Wiley |
| subjects | Cerebrospinal fluid Cord blood Fetuses India infection minimall invasive tissue sampling Observational studies Organisms Pakistan Pathogens PCR Placenta Polymerase chain reaction stillbirth Ureaplasma urealyticum |
| title | Pathogens identified in the internal tissues and placentas of stillbirths: results from the prospective, observational PURPOSe study |
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