Pathogens identified in the internal tissues and placentas of stillbirths: results from the prospective, observational PURPOSe study

Objective To examine internal organ tissues and placentas of stillbirths for various pathogens. Design Prospective, observational study. Settings Three study hospitals in India and a large maternity hospital in Pakistan. Population Stillborn infants delivered in a study hospital. Methods A prospecti...

Full description

Saved in:
Bibliographic Details
Published in:BJOG : an international journal of obstetrics and gynaecology 2023-09, Vol.130 (10), p.1238-1246
Main Authors: Harakuni, Sheetal U., Somannavar, Manjunath S., Ghanchi, Najia K., Ahmed, Imran, Zafar, Afia, Kim, Jean, Tikmani, Shiyam Sunder, Hwang, Kay, Saleem, Sarah, Goudar, Shivaprasad S., Dhaded, Sangappa, Guruprasad, Gowder, Yasmin, Haleema, Yogeshkumar, S., Aceituno, Anna, Silver, Robert M., McClure, Elizabeth M., Goldenberg, R. L., Nagmoti, Mahantesh B, Yogesh Kumar, S, Aradhya, Gayathri H, Nadig, Naveen, Kusgur, Varun, Raghoji, Chaitali R, Siddartha, ES, Patil, Lingaraja Gowda C, Pujar, Sneharoopa, Dhananjaya, Shobha, Sarvamangala, B, Prakash, Veena, Mangala, G K, Rajashekhar, K S, Sunilkumar, K Byranahalli, Kulkarni, Vardendra, Nagaraj, T S, Jeevika, M U, Joish, Upendra Kumar, Harikiran, Reddy R, Uddin, Zeeshan, Ariff, Shabina, Roujani, Sana, Reza, Sayyeda, Bano, Khadija, Raza, Jamal, Parkash, Jai, Parlberg, Lindsay, Moore, Janet L, Parepelli, Suchita, Bann, Carla
Format: Article
Language:English
Subjects:
Cerebrospinal fluid
Cord blood
Fetuses
India
infection
minimall invasive tissue sampling
Observational studies
Organisms
Pakistan
Pathogens
PCR
Placenta
Polymerase chain reaction
stillbirth
Ureaplasma urealyticum
Citations: Items that this one cites
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Objective To examine internal organ tissues and placentas of stillbirths for various pathogens. Design Prospective, observational study. Settings Three study hospitals in India and a large maternity hospital in Pakistan. Population Stillborn infants delivered in a study hospital. Methods A prospective observational study. Main outcome measures Organisms identified by pathogen polymerase chain reaction (PCR) in internal organs and placental tissues of stillbirths. Results Of 2437 stillbirth internal tissues, 8.3% (95% CI 7.2–9.4) were positive. Organisms were most commonly detected in brain (12.3%), cerebrospinal fluid (CSF) (9.5%) and whole blood (8.4%). Ureaplasma urealyticum/parvum was the organism most frequently detected in at least one internal organ (6.4% of stillbirths and 2% of all tissues). Escherichia coli/Shigella was the next most common (4.1% one or more internal organ tissue sample and 1.3% of tissue samples), followed by Staphylococcus aureus in at least one internal organ tissue (1.9% and 0.9% of all tissues). None of the other organisms was found in more than 1.4% of the tissue samples in stillbirths or more than 0.6% of the internal tissues examined. In the placenta tissue, membrane or cord blood combined, 42.8% (95% CI 40.2–45.3) had at least one organism identified, with U. urealyticum/parvum representing the most commonly identified (27.8%). Conclusions In about 8% of stillbirths, there was evidence of a pathogen in an internal organ. Ureaplasma urealyticum/parvum was the most common organism found in the placenta and in the internal tissues, especially in the fetal brain.
ISSN:1470-0328
1471-0528
DOI:10.1111/1471-0528.17479