Outcomes of immunocompromised children hospitalized for Influenza, 2010-2021, the Canadian Immunization Monitoring Program Active (IMPACT)

To evaluate immunocompromising conditions and subgroups of immunocompromise as risk factors for severe outcomes among children admitted for influenza. We performed active surveillance for laboratory-confirmed influenza hospitalizations among children ≤16 years old at the 12 Canadian Immunization Mon...

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Bibliographic Details
Published in:Clinical microbiology and infection 2023-07, Vol.29 (7), p.924-932
Main Authors: Schober, Tilmann, Morris, Shaun K., Bettinger, Julie A., Bancej, Christina, Burton, Catherine, Foo, Cheryl, Halperin, Scott A., Jadavji, Taj, Kazmi, Kescha, Modler, Jacqueline, Sadarangani, Manish, Papenburg, Jesse, Bridger, Natalie, Top, Karina, Thibeault, Roseline, Lebel, Marc, Le Saux, Nicole, Bullard, Jared, Purewal, Rupeena, Sauvé, Laura
Format: Article
Language:English
Subjects:
Adolescent
Canada
Canada - epidemiology
Child
Children
Disease severity
Hospitalization
Hospitalized
Hospitals
Humans
Immunocompromised
Immunodeficiency
Immunosuppression
Influenza
Influenza, Human - complications
Influenza, Human - epidemiology
Influenza, Human - prevention & control
Intensive care
Intensive Care Units
Mortality
Vaccination
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Summary:To evaluate immunocompromising conditions and subgroups of immunocompromise as risk factors for severe outcomes among children admitted for influenza. We performed active surveillance for laboratory-confirmed influenza hospitalizations among children ≤16 years old at the 12 Canadian Immunization Monitoring Program Active hospitals, during 2010–2021. Logistic regression analyses were used to compare outcomes between immunocompromised and non-immunocompromised children, and for different subgroups of immunocompromise. The primary outcome was intensive care unit (ICU) admission; the secondary outcomes were mechanical ventilation and death. Among 8982 children, 892 (9.9%) were immunocompromised; these patients were older (median, 5.6 (IQR, 3.1–10.0) vs. 2.4 (1–6) years; p 
ISSN:1198-743X
1469-0691
DOI:10.1016/j.cmi.2023.04.001