How we approach conservative treatment of retinoblastoma in South America in the era of local ocular treatments: A consensus of the Grupo America Latina de Oncologia Pediatrica (GALOP)

Local therapies are increasingly used for ocular preservation in retinoblastoma. In middle‐income countries, these techniques pose specific challenges mostly related to more advanced disease at diagnosis. The Grupo de America Latina de Oncología Pediátrica (GALOP) developed a consensus document for...

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Published in:Pediatric blood & cancer 2023-07, Vol.70 (7), p.e30352-n/a
Main Authors: Garin, Juan Pablo López, Sampor, Claudia, Grigorovski, Nathalia, Ceciliano, Alejandro, Fandiño, Adriana, Ossandon, Diego, Perez, Verónica, Caixeta, Rafaela, Neto, Joaquim Caetano Aguirre, Alarcón, Sandra, Silva, Sonia, Teixeira, Luiz, Antoneli, Celia Gianotti, Mattosinho, Clarissa, Leal‐Leal, Carlos, Castela, Guilherme, Requejo, Flavio, Catala, Jaume, Macedo, Carla, Chantada, Guillermo L
Format: Article
Language:English
Subjects:
Chemotherapy
Consensus
Conservative Treatment
Enucleation
Hematology
Humans
Infant
intra‐arterial chemotherapy
intra‐vitreal chemotherapy
Oncology
Pediatrics
Radiation therapy
Retinal Neoplasms - drug therapy
Retinoblastoma
Retinoblastoma - drug therapy
Retrospective Studies
South America
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Summary:Local therapies are increasingly used for ocular preservation in retinoblastoma. In middle‐income countries, these techniques pose specific challenges mostly related to more advanced disease at diagnosis. The Grupo de America Latina de Oncología Pediátrica (GALOP) developed a consensus document for the management of conservative therapy for retinoblastoma. Intra‐arterial chemotherapy (OAC) is the preferred therapy, except for those with less advanced disease or age younger than 6 months. OAC allowed for a reduction in the use of external beam radiotherapy in our setting. Intravitreal chemotherapy is the preferred treatment for vitreous seeding. Enucleation is the treatment of choice for eyes with advanced disease.
ISSN:1545-5009
1545-5017
DOI:10.1002/pbc.30352