Dual receptor NIR-II organic nanoparticles for multimodal imaging guided tumor photothermal therapy

The second near-infrared (NIR-II) fluorescence imaging has attracted continuous attention due to its excellent penetration depth and high spatial resolution. Compared with other fluorophores, NIR-II fluorophores, especially NIR-II organic small molecule fluorophores, are favored because of their con...

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Bibliographic Details
Published in:Nanomedicine 2023-06, Vol.50, p.102677-102677, Article 102677
Main Authors: Su, Yingbin, Yuan, Lin, Wang, Yu, Wang, Chang, Cao, Mengyu, Gong, Shida, Cong, Hailin, Yu, Bing, Shen, Youqing
Format: Article
Language:English
Subjects:
Double receptor (A-A) type
Fluorescence/photoacoustic dual-mode imaging (FI/PAI)
Near-infrared second region
Photothermal therapy (PTT)
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Summary:The second near-infrared (NIR-II) fluorescence imaging has attracted continuous attention due to its excellent penetration depth and high spatial resolution. Compared with other fluorophores, NIR-II fluorophores, especially NIR-II organic small molecule fluorophores, are favored because of their controllable structure and good biocompatibility. In this study, we designed and synthesized an S-D-A-D-S type small molecule FEA. However, a new molecule was accidentally obtained in the process of synthesis, which was proved to be a double receptor (A-A) type small molecule, namely S-D-A-A-D-S type organic small molecule FEAA. Compared with FEA molecules, FEAA exhibits superior fluorescence performance and can effectively prevent fluorescence quenching. The fluorescence emission of its nanoparticles (NPs) reaches 1109 nm, extends to about 1400 nm, and has a Stokes shift of up to 472 nm. Subsequently, we realized fluorescence/photoacoustic dual-mode imaging (FI/PAI) of nude mouse liver, and finally effectively ablated 4T1 tumor by photothermal therapy (PTT). In general, FEAA NPs exhibit good fluorescence, photoacoustic, and photothermal effects, and are an excellent multifunctional NIR-II organic small molecule fluorophore. As far as we know, there are few reports on A-A type organic small molecules, most of which are cyanines or D-A-D type structures. Therefore, this study has good exploratory significance and reference value for the discovery of NIR-II fluorophores. We designed and synthesized a dual-acceptor NIR-II organic fluorescent small molecule (FEAA) with high emission wavelength and large Stokes shift. By injecting FEAA NPs through the tail vein of subcutaneous tumor-bearing nude mice, multimodal imaging (fluorescence imaging and photoacoustic imaging) can be achieved, and tumor localization and photothermal therapy in tumor-bearing nude mice can be achieved under the EPR effect. [Display omitted]
ISSN:1549-9634
1549-9642
DOI:10.1016/j.nano.2023.102677