Association of periodontal disease with migraine: A large‐scale community‐based cross‐sectional study

Background Periodontal disease may drive a systemic inflammatory response that triggers migraine; however, the association between periodontal disease and migraine has rarely been investigated in a community‐based setting. Methods This cross‐sectional study included 66,109 participants aged 30 to 70...

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Published in:Headache 2023-04, Vol.63 (4), p.539-548
Main Authors: Chen, Yen‐Ju, Hu, Kai‐Fang, Chan, Chi, Huang, Claire, Huang, Yu‐Han, Wang, Yen‐Feng, Wang, Shuu‐Jiun, Chen, Shih‐Pin, Lee, Mei‐Hsuan
Format: Article
Language:English
Subjects:
biobank
Comorbidity
Cross-Sectional Studies
genetic predisposition
Genetic Predisposition to Disease
Genomes
Genotyping
Gum disease
Headache
Humans
Inflammation
Inflammatory response
Migraine
Migraine Disorders - epidemiology
Migraine Disorders - genetics
Nucleotides
oral hygiene
oral microbiome
Periodontal disease
Periodontal diseases
Polymorphism
Risk Factors
Single-nucleotide polymorphism
Subgroups
Citations: Items that this one cites
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Summary:Background Periodontal disease may drive a systemic inflammatory response that triggers migraine; however, the association between periodontal disease and migraine has rarely been investigated in a community‐based setting. Methods This cross‐sectional study included 66,109 participants aged 30 to 70 years from Taiwan Biobank (TWB). A structured questionnaire was administered to participants, who were also subjected to whole‐genome single nucleotide polymorphism genotyping using the customized Axiom–TWB array. To identify subjects with periodontal disease and migraine, the computerized linkage of data obtained from TWB and the National Health Insurance Research Database was performed. Participants were evaluated for their genetic predisposition to migraine using a polygenic risk score. We examined and estimated the magnitude of associations between periodontal disease and migraine. Results In this study, 4618 (4618/66,109; 7%) participants with migraine and 61,491 (61,491/66,109; 83%) participants without migraine were included. Participants with migraine exhibited a higher prevalence of periodontal disease than participants without migraine (4324/4618; 94% vs. 56,036/61,491; 91%). A significant positive association was observed between periodontal disease and migraine, with an adjusted odds ratio (ORadj) of 1.40 (95% confidence interval [CI] = 1.24–1.59; p 
ISSN:0017-8748
1526-4610
DOI:10.1111/head.14491