Visible-Light-Induced Carbene Insertion into P–H Bonds between Acylsilanes and H‑Phosphorus Oxides

Visible-Light-Induced Carbene Insertion into P–H Bonds between Acylsilanes and H‑Phosphorus Oxides

An intriguing visible-light-induced strategy has been established for the P–H insertion reaction between acylsilanes and H-phosphorus oxides that, upon a subsequent acidic process, deliver a wide variety of α-hydroxyphosphorus oxides in good yields (up to 93% yield). The metal-free protocol represen...

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Bibliographic Details
Published in:Organic letters 2023-04, Vol.25 (13), p.2338-2343
Main Authors: Mo, Xiaoyu, Xie, Yuexiang, Wei, Linli, Gu, Xiu, Zhang, Min, Zhang, Xinzhi, Jiang, Jun
Format: Article
Language:eng
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Summary:An intriguing visible-light-induced strategy has been established for the P–H insertion reaction between acylsilanes and H-phosphorus oxides that, upon a subsequent acidic process, deliver a wide variety of α-hydroxyphosphorus oxides in good yields (up to 93% yield). The metal-free protocol represents a unique example of P–H insertion for C–P bond formation through in situ generation of siloxycarbenes. This methodology features the advantages of operational simplicity, mild conditions, broad substrate scope, and column free in gram-scale synthesis.
ISSN:1523-7060
1523-7052