Pathological Aspects and Immunohistochemical Evaluation of Troponin C in the Cardiovascular System of Dogs With Pheochromocytoma

Functional pheochromocytomas secrete catecholamines and have been associated with cardiovascular lesions in dogs. This study aimed to describe the postmortem pathological findings in the cardiovascular system of dogs with pheochromocytoma and to evaluate the expression of cardiac troponin C in these...

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Published in:Topics in companion animal medicine 2023-03, Vol.53-54, p.100777-100777, Article 100777
Main Authors: Argenta, Fernando F., Slaviero, Mônica, de Mello, Lauren S., Echenique, Joanna V.Z., Zorzan, Alexia A., Cony, Fernanda G., Bandinelli, Marcele B., de Castro, Márcio B., Pavarini, Saulo P., Driemeier, David, Sonne, Luciana
Format: Article
Language:English
Subjects:
adrenal gland neoplasms
Adrenal Gland Neoplasms - complications
Adrenal Gland Neoplasms - metabolism
Adrenal Gland Neoplasms - veterinary
Animals
canines
cardiac troponin
cardiomyopathy
Dog Diseases - pathology
Dogs
immunohistochemistry
Myocardium - metabolism
Myocardium - pathology
Necrosis - complications
Necrosis - metabolism
Necrosis - pathology
Necrosis - veterinary
Pheochromocytoma - complications
Pheochromocytoma - metabolism
Pheochromocytoma - veterinary
Troponin C - metabolism
tyrosine hydroxylase
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Summary:Functional pheochromocytomas secrete catecholamines and have been associated with cardiovascular lesions in dogs. This study aimed to describe the postmortem pathological findings in the cardiovascular system of dogs with pheochromocytoma and to evaluate the expression of cardiac troponin C in these dogs using immunohistochemical analysis. Twelve cases were identified, with a mean age of 10.6 years. The heart of all dogs was enlarged and with concentric hypertrophy of the left ventricular myocardium. Histological analysis showed cardiomyocyte necrosis and degeneration in the myocardium, with frequent bands of contraction, fibrosis, inflammation, and thickening of the medium-caliber arteries in the myocardium. There was a marked decrease or absence of immunolabeling in necrotic cardiomyocytes. We conclude that IHC for troponin C can be a useful tool for detecting myocardial necrosis in dogs with pheochromocytomas, including early cases of necrosis with only incipient cardiac changes where overt histologic abnormalities are not immediately apparent in the cardiomyocytes.
ISSN:1938-9736
1946-9837
DOI:10.1016/j.tcam.2023.100777