Diagnostic performance of Mac-2-binding protein glycosylation isomer (M2BPGi) as a liver fibrosis marker in chronic hepatitis C patients with chronic kidney disease on hemodialysis

Background/aim Liver fibrosis assessment is essential to determine the initiation, duration, and evaluation of chronic hepatitis C treatment. Therefore, the study aimed to assess the role of Mac-2-binding protein glycosylation isomer (M2BPGi) as a biomarker to measure liver fibrosis in chronic hepat...

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Published in:Clinical and experimental nephrology 2023-06, Vol.27 (6), p.557-564
Main Authors: Sulaiman, Andri Sanityoso, Hasan, Irsan, Hustrini, Ni Made, Lydia, Aida, Hanifa, Rachmadianti Sukma, Gani, Rino Alvani
Format: Article
Language:English
Subjects:
Biomarkers
Cross-Sectional Studies
Glycosylation
Hepatitis C, Chronic - complications
Humans
Liver Cirrhosis - diagnosis
Medicine
Medicine & Public Health
Membrane Glycoproteins
Nephrology
Original Article
Renal Dialysis
Renal Insufficiency, Chronic - complications
Renal Insufficiency, Chronic - diagnosis
Renal Insufficiency, Chronic - therapy
Urology
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Summary:Background/aim Liver fibrosis assessment is essential to determine the initiation, duration, and evaluation of chronic hepatitis C treatment. Therefore, the study aimed to assess the role of Mac-2-binding protein glycosylation isomer (M2BPGi) as a biomarker to measure liver fibrosis in chronic hepatitis C patients with chronic kidney disease on hemodialysis. Methods This study used a cross-sectional design. Serum M2BPGi level and transient elastography results were evaluated in 102 chronic hepatitis C patients with CKD on HD, 36 CKD on HD patients, and 48 healthy controls. ROC analysis was conducted to identify the optimal cutoff values to assess significant fibrosis and cirrhosis among chronic hepatitis C patients with CKD on HD. Results In chronic hepatitis C patients with CKD on HD, the level of serum M2BPGi had a moderately significant correlation with transient elastography ( r  = 0.447, p  
ISSN:1342-1751
1437-7799
DOI:10.1007/s10157-023-02319-z