Impact of the bacterial nasopharyngeal microbiota on the severity of genus enterovirus lower respiratory tract infection in children: A case–control study

Introduction Rhinoviruses (RV) and enteroviruses (EV) are among the main causative etiologies of lower respiratory tract infection (LRTI) in children. The clinical spectrum of RV/EV infection is wide, which could be explained by diverse environmental, pathogen‐, and host‐related factors. Little is k...

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Published in:Pediatric pulmonology 2023-06, Vol.58 (6), p.1728-1737
Main Authors: Penela‐Sánchez, Daniel, Rocafort, Muntsa, Henares, Desiree, Jordan, Iolanda, Brotons, Pedro, Cabrerizo, María, Launes, Cristian, Muñoz‐Almagro, Carmen
Format: Article
Language:English
Subjects:
Asymptomatic
Bacteria - genetics
Case-Control Studies
Child
Cross-Sectional Studies
enterovirus
Enterovirus - genetics
Enterovirus Infections - diagnosis
Humans
Infant
Infections
intensive care units
lower respiratory tract infection
Microbiota
Pediatrics
Respiratory Tract Infections - diagnosis
rhinovirus
Rhinovirus - genetics
RNA, Ribosomal, 16S - genetics
Viruses - genetics
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Summary:Introduction Rhinoviruses (RV) and enteroviruses (EV) are among the main causative etiologies of lower respiratory tract infection (LRTI) in children. The clinical spectrum of RV/EV infection is wide, which could be explained by diverse environmental, pathogen‐, and host‐related factors. Little is known about the nasopharyngeal microbiota as a risk factor or disease modifier for RV/EV infection in pediatric patients. This study describes distinct nasopharyngeal microbiota profiles according to RV/EV LRTI status in children. Methods Cross‐sectional case–control study, conducted at Hospital Sant de Déu (Barcelona, Spain) from 2017 to 2020. Three groups of children
ISSN:8755-6863
1099-0496
DOI:10.1002/ppul.26393