Unpublished clinical trials of common rheumatic diseases

Abstract Objectives Randomized controlled trials (RCTs) provide high-quality evidence for treatment efficacy, but many RCTs remain unpublished. The objective of this study was to describe the proportion of unpublished RCTs in five rheumatic diseases and to identify factors associated with publicatio...

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Bibliographic Details
Published in:Rheumatology (Oxford, England) England), 2023-12, Vol.62 (12), p.3811-3818
Main Authors: Pedersen, Connor, Tai, Shannon, Valley, Erin, Henry, Kathryn, Duarte-García, Alí, Singla, Shikha, Putman, Michael
Format: Article
Language:English
Subjects:
Arthritis, Psoriatic
Humans
Registries
Rheumatic Diseases - drug therapy
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Summary:Abstract Objectives Randomized controlled trials (RCTs) provide high-quality evidence for treatment efficacy, but many RCTs remain unpublished. The objective of this study was to describe the proportion of unpublished RCTs in five rheumatic diseases and to identify factors associated with publication. Methods Registered RCTs for five rheumatic diseases (SLE, vasculitis, spondyloarthritis, SS and PsA) with over 30 months since study completion were identified using ClinicalTrials.gov. Index publications were identified by NCT ID numbers and structured text searches of publication databases. The results of unpublished studies were identified in abstracts and press releases; reasons for non-publication were assessed by surveying corresponding authors. Results Out of 203 studies that met eligibility criteria, 17.2% remained unpublished, representing data from 4281 trial participants. Higher proportions of published trials were phase 3 RCTs (57.1% vs 28.6% unpublished, P 
ISSN:1462-0324
1462-0332
DOI:10.1093/rheumatology/kead141