Epithelial salivary gland tumors in pediatric patients: An international collaborative study

Salivary gland tumors (SGT) are a diverse group of uncommon neoplasms that are rare in pediatric patients. This study aimed to characterize the clinicopathological profile of pediatric patients affected by SGT from a large case series derived from an international group of academic centers. A retros...

Full description

Saved in:
Bibliographic Details
Published in:International journal of pediatric otorhinolaryngology 2023-05, Vol.168, p.111519-111519, Article 111519
Main Authors: Quixabeira Oliveira, Gabriella Alves, Pérez-DE-Oliveira, Maria Eduarda, Robinson, Liam, Khurram, Syed Ali, Hunter, Keith, Speight, Paul M., Kowalski, Luiz Paulo, Lopes Pinto, Clóvis Antonio, Sales De Sá, Raísa, Mendonça, Elismauro Francisco, Sousa-Neto, Sebastião Silvério, de Carlucci Junior, Dorival, Mariano, Fernanda Viviane, Altemani, Albina Messias de Almeida Milani, Martins, Manoela Domingues, Zanella, Virgílio Gonzales, Perez, Danyel Elias da Cruz, dos Santos, Jean Nunes, Romañach, Mário José, Abrahão, Aline Corrêa, Andrade, Bruno Augusto Benevenuto de, Pontes, Hélder Antônio Rebelo, Jorge Junior, Jacks, Santos-Silva, Alan Roger, Lopes, Márcio Ajudarte, Van Heerden, Willie F.P., Vargas, Pablo Agustin
Format: Article
Language:English
Subjects:
Adenoma, Pleomorphic - epidemiology
Adenoma, Pleomorphic - pathology
Adenoma, Pleomorphic - surgery
Adolescent
Adult
Carcinoma, Mucoepidermoid - pathology
Child
Child, Preschool
Children
Epidemiology
Female
Head and neck cancer
Humans
Infant
Infant, Newborn
Retrospective Studies
Salivary Gland Neoplasms - epidemiology
Salivary Gland Neoplasms - surgery
Salivary Glands - pathology
Salivary Glands - surgery
Salivary glands tumors
Survival
Young Adult
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Salivary gland tumors (SGT) are a diverse group of uncommon neoplasms that are rare in pediatric patients. This study aimed to characterize the clinicopathological profile of pediatric patients affected by SGT from a large case series derived from an international group of academic centers. A retrospective analysis of pediatric patients with SGT (0–19 years old) diagnosed between 2000 and 2021 from Brazil, South Africa, and the United Kingdom was performed. SPSS Statistics for Windows was used for a quantitative analysis of the data, with a descriptive analysis of the clinicopathological characteristics and the association between clinical variables and diagnoses. A total of 203 cases of epithelial SGT were included. Females were slightly more commonly (56.5%), with a mean age of 14.1 years. The palate was the most common site (43.5%), followed by the parotid gland (29%), lip (10%), and submandibular gland (7.5%). The predominant clinical presentation was a flesh-colored, smooth, and painless nodule. Pleomorphic adenoma (PA) was the most frequently diagnosed SGT (58.6%), followed by mucoepidermoid carcinoma (MEC) (26.6%). Surgery (90.8%) was the favored treatment option. Benign SGT in pediatric patients are more commonly benign than malignant tumors. Clinicians should keep PA and MEC in mind when assessing nodular lesions of possible salivary gland origin in pediatric patients.
ISSN:0165-5876
1872-8464
DOI:10.1016/j.ijporl.2023.111519