Physical activity‐induced alterations of the gut microbiota are BMI dependent

Physical inactivity is one of the leading causes of chronic metabolic disease including obesity. Increasing physical activity (PA) has been shown to improve cardiometabolic and musculoskeletal health and to be associated with a distinct gut microbiota composition in trained athletes. However, the im...

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Bibliographic Details
Published in:The FASEB journal 2023-04, Vol.37 (4), p.e22882-n/a
Main Authors: Shah, Shrushti, Mu, Chunlong, Moossavi, Shirin, Shen‐Tu, Grace, Schlicht, Kristina, Rohmann, Nathalie, Geisler, Corinna, Laudes, Matthias, Franke, Andre, Züllig, Thomas, Köfeler, Harald, Shearer, Jane
Format: Article
Language:English
Subjects:
Adult
Body Mass Index
Gastrointestinal Microbiome - genetics
hand‐grip strength
Humans
lipidomics
Male
microbiome
Microbiota
Middle Aged
Obesity - microbiology
Overweight
physical activity
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Summary:Physical inactivity is one of the leading causes of chronic metabolic disease including obesity. Increasing physical activity (PA) has been shown to improve cardiometabolic and musculoskeletal health and to be associated with a distinct gut microbiota composition in trained athletes. However, the impact of PA on the gut microbiota is inconclusive for individuals performing PA in their day‐to‐day life. This study examined the role of PA and hand‐grip strength on gut microbiome composition in middle‐aged adults (40–65 years, n = 350) with normal (18.5–24.9 kg/m2) and overweight (25–29.9 kg/m2) body mass index (BMI). PA was recorded using the International Physical Activity Questionnaire, and hand‐grip strength was measured using a dynamometer. Serum samples were assessed for lipidomics while DNA was extracted from fecal samples for microbiome analysis. Overweight participants showed a higher concentration of triacylglycerols, and lower concentrations of cholesteryl esters, sphingomyelin, and lyso‐phosphotidylcholine lipids (p 
ISSN:0892-6638
1530-6860
DOI:10.1096/fj.202201571R