Cysteine carboxyethylation generates neoantigens to induce HLA-restricted autoimmunity

Autoimmune diseases such as ankylosing spondylitis (AS) can be driven by emerging neoantigens that disrupt immune tolerance. Here, we developed a workflow to profile posttranslational modifications involved in neoantigen formation. Using mass spectrometry, we identified a panel of cysteine residues...

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Bibliographic Details

Published in:	Science (American Association for the Advancement of Science) 2023-03, Vol.379 (6637), p.eabg2482-eabg2482
Main Authors:	Zhai, Yue, Chen, Liang, Zhao, Qian, Zheng, Zhao-Hui, Chen, Zhi-Nan, Bian, Huijie, Yang, Xu, Lu, Huan-Yu, Lin, Peng, Chen, Xi, Chen, Ruo, Sun, Hao-Yang, Fan, Lin-Ni, Zhang, Kun, Wang, Bin, Sun, Xiu-Xuan, Feng, Zhuan, Zhu, Yu-Meng, Zhou, Jian-Sheng, Chen, Shi-Rui, Zhang, Tao, Chen, Si-Yu, Chen, Jun-Jie, Zhang, Kui, Wang, Yan, Chang, Yang, Zhang, Rui, Zhang, Bei, Wang, Li-Juan, Li, Xiao-Min, He, Qian, Yang, Xiang-Min, Nan, Gang, Xie, Rong-Hua, Yang, Liu, Yang, Jing-Hua, Zhu, Ping
Format:	Article
Language:	eng
Subjects:	Animals Autoantibodies - metabolism Autoimmune Diseases - genetics Autoimmune Diseases - metabolism Autoimmunity - genetics Autoimmunity - immunology Cysteine - metabolism Gastrointestinal Microbiome HLA-DRB1 Chains - genetics HLA-DRB1 Chains - metabolism Humans Integrin alpha2 - metabolism Mice Mice, Transgenic Protein Processing, Post-Translational Spondylitis, Ankylosing - genetics Spondylitis, Ankylosing - metabolism
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