Simultaneous assessment of left ventricular mechanical dyssynchrony using integrated 13N-ammonia PETMR system: direct comparison of PET phase analysis and MR feature tracking

To compare phase analysis with positron emission tomography (PA) and magnetic resonance feature tracking derived myocardial strain (FT) for left ventricular (LV) mechanical dyssynchrony using PETMR system in patients with ischemic heart disease. Patients who underwent rest-pharmacological stress 13N...

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Bibliographic Details
Published in:Journal of nuclear cardiology 2023-10, Vol.30 (5), p.1947-1958
Main Authors: Fukushima, Kenji, Endo, Keiichiro, Yamakuni, Ryo, Kiko, Takatoyo, Sekino, Hirofumi, Kikori, Katsuyuki, Ukon, Naoyuki, Ishii, Shiro, Yamaki, Takayoshi, Ito, Hiroshi, Takeishi, Yasuchika
Format: Article
Language:English
Subjects:
Cardiology
Imaging
Left ventricular dyssynchrony
Medicine
Medicine & Public Health
MRI
myocardial strain
Nuclear Medicine
Original Article
PET
phase analysis
Radiology
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Summary:To compare phase analysis with positron emission tomography (PA) and magnetic resonance feature tracking derived myocardial strain (FT) for left ventricular (LV) mechanical dyssynchrony using PETMR system in patients with ischemic heart disease. Patients who underwent rest-pharmacological stress 13N ammonia PETMR were enrolled. Histogram bandwidth (BW) and phase standard deviation (PSD) were compared to global longitudinal, long axis radial, short axis circumferential, and radial strain (GLS, GRS, SA Circ, and SA Rad) obtained from FT. LV dyssynchrony index (SDI) derived from PA and FT were compared. BW and PSD showed significant correlations with FT (a Pearson’s coefficient r = 0.64, P < .0001, and r = 0.51, P < .0001 for SA Circ; r = 0.67, P < .0001, and r = 0.74, P < .0001 for GLS; r = − 0.60, P < .0001, r = − 0.61, P < .0001 for SA Rad; r = − 0.62, P < .0001, and r = − 0.68, P < .0001 for GRS, respectively). Bland-Altman plots for SDI showed a preferable agreement (95% limit of agreement − 0.12 to 0.075, − 0.20 to 0.098, − 0.38 to 0.077, and − 0.37 to 0.032; bias 0.0068 ± 0.056, 0.026 ± 0.068, 0.11 ± 0.088, and 0.13 ± 0.079 for SA Circ, SA Rad, GLS, and GRS, respectively). In simultaneous acquisition using PETMR, comparison of PET phase analysis and MR strain showed a good correlation.
ISSN:1071-3581
1532-6551
DOI:10.1007/s12350-023-03225-3