Long-term effects of COVID-19 on lungs and the clinical relevance: a 6-month prospective cohort study

We aimed to explore the prevalence of prolonged symptoms, pulmonary impairments and residual disease on chest tomography (CT) in COVID-19 patients at 6 months after acute illness. In this prospective, single-center study, hospitalized patients with radiologically and laboratory-confirmed COVID-19 we...

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Bibliographic Details
Published in:Future microbiology 2023-03, Vol.18 (4), p.185-198
Main Authors: Tuncer, Gulsah, Geyiktepe-Guclu, Ceyda, Surme, Serkan, Canel-Karakus, Evren, Erdogan, Hatice, Bayramlar, Osman F, Belge, Cansu, Karahasanoglu, Ridvan, Copur, Betul, Yazla, Meltem, Zerdali, Esra, Nakir, Inci Y, Yildirim, Nihal, Kar, Bedriye, Bozkurt, Mediha, Karanalbant, Kubra, Atasoy, Burcu, Takak, Hindirin, Simsek-Yavuz, Serap, Turkay, Rustu, M Sonmez, Mehmet, Sengoz, Gonul, Pehlivanoglu, Filiz
Format: Article
Language:English
Subjects:
chest CT
COVID-19
Disease Progression
follow-up
Humans
Laboratories
Lung - diagnostic imaging
Prospective Studies
pulmonary function
residual disease
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Summary:We aimed to explore the prevalence of prolonged symptoms, pulmonary impairments and residual disease on chest tomography (CT) in COVID-19 patients at 6 months after acute illness. In this prospective, single-center study, hospitalized patients with radiologically and laboratory-confirmed COVID-19 were included. A high proportion of the 116 patients reported persistent symptoms (n = 54; 46.6%). On follow-up CT, 33 patients (28.4%) demonstrated residual disease. Multivariate analyses revealed that only neutrophil-to-lymphocyte ratio was an independent predictor for residual disease. Hospitalized patients with mild/moderate COVID-19 still had persistent symptoms and were prone to develop long-term pulmonary sequelae on chest CT. However, it did not have a significant effect on long-term pulmonary functions.
ISSN:1746-0913
1746-0921
DOI:10.2217/fmb-2022-0121