Copper-Catalyzed Direct Carbonylation of Carbenes toward the Synthesis of Propanedioic Acid Derivatives

Carbenes are highly active reaction intermediates, which can be used as reaction precursors to modify organisms, drugs, and material molecules. In this work, we realized a new cheap metal-catalyzed carbonylation of carbene to give propanedioic acid derivatives. With copper salt as the catalyst, synt...

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Bibliographic Details
Published in:Organic letters 2023-03, Vol.25 (11), p.1963-1968
Main Authors: Yang, Hefei, Bao, Zhi-Peng, Wang, Le-Cheng, Wu, Xiao-Feng
Format: Article
Language:English
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Summary:Carbenes are highly active reaction intermediates, which can be used as reaction precursors to modify organisms, drugs, and material molecules. In this work, we realized a new cheap metal-catalyzed carbonylation of carbene to give propanedioic acid derivatives. With copper salt as the catalyst, synthetically important malonates and related compounds were produced in good yields under mild reaction conditions.
ISSN:1523-7060
1523-7052
DOI:10.1021/acs.orglett.3c00506