Functioning of P-Glycoprotein during Pregnancy in Rabbits

The level P-glycoprotein (Pgp) in organs of pregnant rabbits and its content and activity in the placental barrier at different stages of pregnancy were studied. An increase in Pgp content in the jejunum on days 7, 14, 21, and 28 of pregnancy in comparison with this parameter non-pregnant females wa...

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Bibliographic Details
Published in:Bulletin of experimental biology and medicine 2023-02, Vol.174 (4), p.431-434
Main Authors: Popova, N. M., Shchulkin, A. V., Chernykh, I. V., Mylnikov, P. Yu, Yakusheva, E. N.
Format: Article
Language:English
Subjects:
Animals
ATP Binding Cassette Transporter, Subfamily B
ATP Binding Cassette Transporter, Subfamily B, Member 1
Biomedical and Life Sciences
Biomedicine
Biophysics and Biochemistry
Cell Biology
Cerebral cortex
Drug dosages
Female
Females
Fetuses
Fexofenadine
Glycoproteins
Hormones
Internal Medicine
Jejunum
Kidneys
Laboratory animals
Laboratory Medicine
Liver
P-Glycoprotein
Pathology
Placenta
Pregnancy
Pregnant women
Progesterone
Proteins
Rabbits
Renal cortex
Small intestine
Test systems
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Summary:The level P-glycoprotein (Pgp) in organs of pregnant rabbits and its content and activity in the placental barrier at different stages of pregnancy were studied. An increase in Pgp content in the jejunum on days 7, 14, 21, and 28 of pregnancy in comparison with this parameter non-pregnant females was revealed by ELISA; in the liver, Pgp content was higher on day 7 and tended to increase on day 14; in the kidney and cerebral cortex, Pgp content was higher on day 28 of pregnancy in parallel with an increase in serum progesterone concentration. We also observed a decrease in Pgp content in the placenta on days 21 and 28 of pregnancy in comparison with day 14 and a decrease in Pgp activity in the placental barrier, which was confirmed by enhanced penetration of fexofenadine (Pgp substrate) through the barrier.
ISSN:0007-4888
1573-8221
DOI:10.1007/s10517-023-05723-3