Head and neck cancer biomarkers: Systematic review and meta-analysis

•This meta-analysis and systematic review demonstrate that many diagnostics categories emerged as potentially promising in diagnosing HNC.•The combinations of biomarkers miR-196a + miR-196b, Propionate + Acetone + Acetate + Choline, and pGSN + sFasL revealed the greatest DTA.•Total 35 single biomark...

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Bibliographic Details
Published in:Clinica chimica acta 2023-03, Vol.542, p.117280-117280, Article 117280
Main Author: Marakala, Vijaya
Format: Article
Language:English
Subjects:
Biological markers
Biomarkers
Biomarkers, Tumor
Combined biomarkers
Diagnosis
Head and neck cancer
Head and Neck Neoplasms - diagnosis
Humans
Individual biomarkers
Plasma
Saliva
Saliva - chemistry
Sensitivity and Specificity
Serum
Tissue
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Summary:•This meta-analysis and systematic review demonstrate that many diagnostics categories emerged as potentially promising in diagnosing HNC.•The combinations of biomarkers miR-196a + miR-196b, Propionate + Acetone + Acetate + Choline, and pGSN + sFasL revealed the greatest DTA.•Total 35 single biomarkers possess excellent specificity, while only three combined or mixed biomarkers have good sensitivity. To perform a systematic review and meta-analysis of the diagnostic capabilities of various biological markers in the plasma, serum, tissue, and saliva of patients with head and neck cancer (HNC). We performed manual and digital searches using specific keywords and found English-language literature published up to October 28, 2022. PubMed, ScienceDirect, Scopus, MEDLINE Complete, and EMBASE databases were used. Studies comparing biomarkers for the diagnosis of HNC versus healthy controls were evaluated. Seventeen studies using varied sources of biomarkers, both individually and combined, were identified. The sensitivity and specificity of biomarkers ranged from 29.5% to 100% and 57.1% to 100%, respectively. The combined biomarkers demonstrated higher therapeutic applicability in terms of sensitivity and specificity than the individual biomarkers. Furthermore, the heterogeneity of the sensitivity/specificity for individual and combined biomarker was 534.45/1.66 and 247.41/14.62, respectively. Combined biomarkers may aid in the diagnosis of HNC. Further studies are required to verify the accuracy of these biomarkers.
ISSN:0009-8981
1873-3492
DOI:10.1016/j.cca.2023.117280